Structural and Functional Characterization of Dynamic Oligomerization in

Adenosine Triphosphate / chemistry Bacterial Proteins / chemistry Burkholderia cenocepacia / enzymology Coenzyme A / chemistry Crystallography, X-Ray Enzyme Assays Hydroxymethylglutaryl CoA Reductases / chemistry Molecular Dynamics Simulation Protein Multimerization Protein Structure, Quaternary Recombinant Proteins / chemistry

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
24 09 2019
Historique:
pubmed: 31 8 2019
medline: 20 6 2020
entrez: 31 8 2019
Statut: ppublish

Résumé

The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR), in most organisms, catalyzes the four-electron reduction of the thioester (

Identifiants

DOI: 10.1021/acs.biochem.9b00494 PMID: 31469273
pubmed: 31469273
doi: 10.1021/acs.biochem.9b00494
doi:

Substances chimiques

Bacterial Proteins 0
Recombinant Proteins 0
Adenosine Triphosphate 8L70Q75FXE
Hydroxymethylglutaryl CoA Reductases EC 1.1.1.-
Coenzyme A SAA04E81UX

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3960-3970

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States

Auteurs

Riley B Peacock (RB)

Department of Chemistry and Biochemistry , Gonzaga University , Spokane , Washington 99258 , United States.

Chad W Hicks (CW)

Department of Chemistry and Biochemistry , Gonzaga University , Spokane , Washington 99258 , United States.

Alexander M Walker (AM)

Department of Chemistry , Washington State University , Pullman , Washington 99164 , United States.

Sophia M Dewing (SM)

Department of Chemistry and Biochemistry , Gonzaga University , Spokane , Washington 99258 , United States.

Kevin M Lewis (KM)

Department of Chemistry , Washington State University , Pullman , Washington 99164 , United States.

Jean-Claude Abboud (JC)

Department of Chemistry and Biochemistry , Gonzaga University , Spokane , Washington 99258 , United States.

Samuel W A Stewart (SWA)

Department of Chemistry and Biochemistry , Gonzaga University , Spokane , Washington 99258 , United States.

ChulHee Kang (C)

Department of Chemistry , Washington State University , Pullman , Washington 99164 , United States.

Jeffrey M Watson (JM)

Department of Chemistry and Biochemistry , Gonzaga University , Spokane , Washington 99258 , United States.
ORCID: 0000-0002-6939-0137

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Structural and Functional Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Structural and Functional Characterization of...
questionsmedicales.fr › Bactéries › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia › Structural and Functional Characterization of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Structural and Functional Characterization of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural and Functional Characterization of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Dosages enzymatiques › Structural and Functional Characterization of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › 3-Hydroxyacyl-CoA dehydrogenases › Hydroxymethylglutaryl-CoA reductases › Structural and Functional Characterization of...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Structural and Functional Characterization of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Structural and Functional Characterization of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure quaternaire des protéines › Structural and Functional Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Structural and Functional Characterization of...