Ischemic Neuroprotectant PKCε Restores Mitochondrial Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle after Ischemic Injury.

Animals Aspartate Aminotransferase, Mitochondrial / metabolism Brain Ischemia / enzymology Malates / metabolism Male NAD / metabolism Neurons / enzymology Phosphorylation Primary Cell Culture Protein Kinase C-epsilon / metabolism Rats, Sprague-Dawley
Cerebral ischemia Conditioning Ischemia tolerance Ischemic preconditioning Malate aspartate shuttle Mitochondria

Journal

Translational stroke research
ISSN: 1868-601X
Titre abrégé: Transl Stroke Res
Pays: United States
ID NLM: 101517297

Informations de publication

Date de publication:
06 2020
Historique:
received: 25 06 2019
accepted: 20 08 2019
revised: 13 08 2019
pubmed: 2 9 2019
medline: 28 7 2021
entrez: 2 9 2019
Statut: ppublish

Résumé

The preservation of mitochondrial function is a major protective strategy for cerebral ischemic injuries. Previously, our laboratory demonstrated that protein kinase C epsilon (PKCε) promotes the synthesis of mitochondrial nicotinamide adenine dinucleotide (NAD

Identifiants

DOI: 10.1007/s12975-019-00729-4 PMID: 31473978 PMC: PMC7048657
pubmed: 31473978
doi: 10.1007/s12975-019-00729-4
pii: 10.1007/s12975-019-00729-4
pmc: PMC7048657
mid: NIHMS1538787
doi:

Substances chimiques

Malates 0
NAD 0U46U6E8UK
malic acid 817L1N4CKP
Aspartate Aminotransferase, Mitochondrial EC 2.6.1.-
Prkce protein, rat EC 2.7.1.-
Protein Kinase C-epsilon EC 2.7.11.13

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

418-432

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS045676
Pays : United States
Organisme : NINDS NIH HHS
ID : NS45676
Pays : United States
Organisme : American Heart Association
ID : 19PRE34400074
Pays : International
Organisme : NINDS NIH HHS
ID : R29 NS034773
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS054147
Pays : United States
Organisme : NINDS NIH HHS
ID : NS34773
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097658
Pays : United States
Organisme : NINDS NIH HHS
ID : NS097658
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS034773
Pays : United States
Organisme : NINDS NIH HHS
ID : NS45676
Pays : United States
Organisme : NINDS NIH HHS
ID : NS097658
Pays : United States
Organisme : NINDS NIH HHS
ID : NS34773
Pays : United States

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Auteurs

Jing Xu (J)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA.
Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
ORCID: 0000-0002-1119-7959

Nathalie Khoury (N)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA.
Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Charles W Jackson (CW)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA.
Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Iris Escobar (I)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA.
Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Samuel D Stegelmann (SD)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA.

Kunjan R Dave (KR)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA.
Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA.

Miguel A Perez-Pinzon (MA)

Peritz Scheinberg Cerebral Vascular Disease Research Laboratories, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA. perezpinzon@med.miami.edu.
Department of Neurology, University of Miami Leonard M. Miller School of Medicine, P.O. Box 016960, Miami, FL, 33136, USA. perezpinzon@med.miami.edu.
Neuroscience Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL, 33136, USA. perezpinzon@med.miami.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Aspartate aminotransferase, mitochondrial › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Malates › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Cellules › Neurones › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Métabolisme › Phosphorylation › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Culture de cellules primaires › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Protéine kinase C › Protein kinase C-epsilon › Ischemic Neuroprotectant PKCε Restores...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Ischemic Neuroprotectant PKCε Restores...