Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects.
Ascorbic acid
Dendritic spines
Hippocampus
Ketamine
Synaptic proteins
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
10 01 2020
10 01 2020
Historique:
received:
11
05
2019
revised:
13
08
2019
accepted:
29
08
2019
pubmed:
3
9
2019
medline:
5
1
2021
entrez:
3
9
2019
Statut:
ppublish
Résumé
Growing evidence has suggested that ascorbic acid may exhibit rapid anxiolytic and antidepressant-like effects. In this study the effects of a single administration of ascorbic acid (1 mg/kg, p.o.), ketamine (1 mg/kg, i.p., a fast-acting antidepressant) and fluoxetine (10 mg/kg, p.o., conventional antidepressant) were investigated on: a) behavioral performance in the novelty suppressed feeding (NSF) test; b) hippocampal synaptic protein immunocontent; c) dendritic spine density and morphology in the dorsal and ventral dentate gyrus (DG) of the hippocampus and d) hippocampal dendritic arborization. Ascorbic acid or ketamine, but not fluoxetine, decreased the latency to feed in the NSF test in mice. This effect was accompanied by increased p70S6K (Thr
Identifiants
pubmed: 31476335
pii: S0278-5846(19)30405-1
doi: 10.1016/j.pnpbp.2019.109757
pii:
doi:
Substances chimiques
Excitatory Amino Acid Antagonists
0
Ketamine
690G0D6V8H
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109757Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.