Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation.

Aniline Compounds / pharmacology Animals Brain / diagnostic imaging Contrast Media Disease Models, Animal Drug Therapy, Combination / methods Encephalomyelitis, Autoimmune, Experimental / diagnostic imaging Female Gadolinium Glatiramer Acetate / pharmacology Image Enhancement / methods Immunosuppressive Agents / pharmacology Magnetic Resonance Imaging / methods Mice Peroxidase / drug effects Saline Solution / administration & dosage

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
10 2019
Historique:
pubmed: 4 9 2019
medline: 11 3 2020
entrez: 4 9 2019
Statut: ppublish

Résumé

Background Despite advances in immunomodulatory agents, most current therapies for multiple sclerosis target lymphocytes or lymphocytic function. However, therapy response may be less than optimal due to demyelination and axonal damage caused by myeloid cells. Purpose To determine if myeloperoxidase (MPO) molecular MRI can evaluate whether combination therapy targeting both lymphoid and myeloid inflammation can improve autoimmune neuroinflammation compared with either drug alone, even at suboptimal doses. Materials and Methods Four groups of 94 female mice (8-10 weeks old) were induced with experimental autoimmune encephalomyelitis (EAE) from August 2, 2016, to March 30, 2018, and divided into saline control (

Identifiants

DOI: 10.1148/radiol.2019182492 PMID: 31478802 PMC: PMC6776885
pubmed: 31478802
doi: 10.1148/radiol.2019182492
pmc: PMC6776885
doi:

Substances chimiques

Aniline Compounds 0
Contrast Media 0
Immunosuppressive Agents 0
Saline Solution 0
4-aminobenzhydrazide 5351-17-7
Glatiramer Acetate 5M691HL4BO
Gadolinium AU0V1LM3JT
Peroxidase EC 1.11.1.7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158-165

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS103998
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS070835
Pays : United States

Commentaires et corrections

Type : CommentIn

Références

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Auteurs

Anning Li (A)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).

Yue Wu (Y)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).

Benjamin Pulli (B)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).

Gregory R Wojtkiewicz (GR)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0002-3148-8411

Yoshiko Iwamoto (Y)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0002-3723-1043

Cuihua Wang (C)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0003-3417-6947

Jing-Hui Li (JH)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0002-5095-3921

Muhammad Ali (M)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).

Xiaoyuan Feng (X)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0003-4525-7494

Zhenwei Yao (Z)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0002-5681-4308

John W Chen (JW)

From the Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, Boston, Mass 02114 (A.L., Y.W., B.P., G.R.W., Y.I., C.W., J.L., M.A., J.W.C.); Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Mass (B.P., C.W., J.W.C.); Department of Radiology, Qilu Hospital of Shandong University, Jinan, China (A.L.); and Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China (A.L., Y.W., X.F., Z.Y.).
ORCID: 0000-0001-7388-9590

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Maladie neurologique auto-immune expérimentale › Encéphalomyélite auto-immune expérimentale › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Terres rares › Lanthanides › Gadolinium › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Acétate de glatiramère › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Amélioration d'image › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Peroxidases › Myeloperoxidase › Myeloperoxidase Molecular MRI Reveals...
questionsmedicales.fr › Préparations pharmaceutiques › Solutions › Solution isotonique › Cristalloïdes › Solution physiologique salée › Myeloperoxidase Molecular MRI Reveals...