Consequence of Hapten Stereochemistry: An Efficacious Methamphetamine Vaccine.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
11 09 2019
11 09 2019
Historique:
pubmed:
4
9
2019
medline:
24
9
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
Recent trends in methamphetamine (METH) misuse and overdose suggest society is inadvertently overlooking a brewing METH crisis. In the past decade, psychostimulant-related lethal overdoses and hospitalizations have skyrocketed 127 and 245%, respectively. Unlike the opioid crisis, no pharmaceutical interventions are available for treating METH use disorder or reversing overdose. Herein, we report the first active vaccine that offers protection from lethal (+)-METH challenge in male Swiss Webster mice. This vaccine formulation of (
Identifiants
pubmed: 31479256
doi: 10.1021/jacs.9b07294
pmc: PMC10681097
mid: NIHMS1943159
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antibodies
0
Haptens
0
Vaccines
0
Methamphetamine
44RAL3456C
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14089-14092Subventions
Organisme : NIDA NIH HHS
ID : F32 DA044692
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA024705
Pays : United States
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