Risk of ischemic stroke and utility of CHA
CHA2DS2-VASc risk score
atrial fibrillation
ischemic stroke
Journal
Clinical cardiology
ISSN: 1932-8737
Titre abrégé: Clin Cardiol
Pays: United States
ID NLM: 7903272
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
02
04
2019
revised:
07
08
2019
accepted:
26
08
2019
pubmed:
7
9
2019
medline:
18
2
2020
entrez:
7
9
2019
Statut:
ppublish
Résumé
The magnitude of increased risk of stroke in women with atrial fibrillation (AF) remains uncertain. We investigated the risk of ischemic stroke and death in women and men with AF, and the risk associated with individual non-sex CHA Retrospective cohort study of 231 077 (48.1% women) nonselected patients with AF not receiving oral anticoagulation from 2006 to 2014. Data from cross-linked national Swedish registers. The outcome was the first occurrence of ischemic stroke or death. Median age was 82 and 75 years in women and men, respectively. Mean follow-up was 2.5 years. Hazard ratios, adjusted for non-sex CHA The risk of ischemic stroke was 1.5-fold higher in women compared to men but this association appears to be the result of confounding by age. In the low risk end, the CHA
Sections du résumé
BACKGROUND
BACKGROUND
The magnitude of increased risk of stroke in women with atrial fibrillation (AF) remains uncertain.
HYPOTHESIS
OBJECTIVE
We investigated the risk of ischemic stroke and death in women and men with AF, and the risk associated with individual non-sex CHA
METHODS
METHODS
Retrospective cohort study of 231 077 (48.1% women) nonselected patients with AF not receiving oral anticoagulation from 2006 to 2014. Data from cross-linked national Swedish registers. The outcome was the first occurrence of ischemic stroke or death. Median age was 82 and 75 years in women and men, respectively. Mean follow-up was 2.5 years.
RESULTS
RESULTS
Hazard ratios, adjusted for non-sex CHA
CONCLUSIONS
CONCLUSIONS
The risk of ischemic stroke was 1.5-fold higher in women compared to men but this association appears to be the result of confounding by age. In the low risk end, the CHA
Identifiants
pubmed: 31490011
doi: 10.1002/clc.23257
pmc: PMC6788468
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1003-1009Informations de copyright
© 2019 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.
Références
Circulation. 2018 Feb 20;137(8):832-840
pubmed: 29459469
BMJ. 2012 May 30;344:e3522
pubmed: 22653980
J Am Coll Cardiol. 2015 Feb 24;65(7):635-42
pubmed: 25677422
Clin Cardiol. 2019 Oct;42(10):1003-1009
pubmed: 31490011
Int J Cardiol. 2014 Nov 15;177(1):91-9
pubmed: 25499348
Arch Intern Med. 1994 Jul 11;154(13):1449-57
pubmed: 8018000
Heart. 2017 Feb;103(3):210-218
pubmed: 27580623
Chest. 2010 Feb;137(2):263-72
pubmed: 19762550
BMJ Open. 2017 Mar 6;7(3):e014579
pubmed: 28264833
Circulation. 2005 Sep 20;112(12):1687-91
pubmed: 16157766
Circulation. 2019 Jul 9;140(2):e125-e151
pubmed: 30686041
Stroke. 1999 Jun;30(6):1223-9
pubmed: 10356104
Eur Heart J. 2019 May 14;40(19):1504-1514
pubmed: 30605505
QJM. 2014 Dec;107(12):955-67
pubmed: 24633256
J Am Coll Cardiol. 2015 Jul 28;66(4):488-90
pubmed: 26205604
J Am Coll Cardiol. 2015 Jan 27;65(3):225-32
pubmed: 25614418
Europace. 2016 Nov;18(11):1609-1678
pubmed: 27567465
PLoS One. 2018 Jan 25;13(1):e0191592
pubmed: 29370229
Med J Aust. 2018 Oct 15;209(8):356-362
pubmed: 30067936
JAMA. 2003 Aug 27;290(8):1049-56
pubmed: 12941677
J Thromb Haemost. 2012 Sep;10(9):1745-51
pubmed: 22805071
Circulation. 2001 May 15;103(19):2365-70
pubmed: 11352885