Chronology and Determinants of Respiratory Function Changes Following Administration of Systemic Postnatal Corticosteroids in Extremely Preterm Infants.
Bronchopulmonary Dysplasia
/ diagnosis
Circadian Rhythm
/ physiology
Dexamethasone
/ administration & dosage
Female
Follow-Up Studies
Gestational Age
Glucocorticoids
/ administration & dosage
Humans
Infant
Infant, Extremely Premature
Infant, Newborn
Intensive Care Units, Neonatal
Male
Oxygen Consumption
Postnatal Care
/ methods
Respiration, Artificial
/ methods
Retrospective Studies
Tidal Volume
/ physiology
Treatment Outcome
corticosteroids
preterm-born infants
respiratory function
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
29
04
2019
revised:
29
06
2019
accepted:
24
07
2019
pubmed:
11
9
2019
medline:
19
5
2020
entrez:
11
9
2019
Statut:
ppublish
Résumé
To describe the effect of systemic corticosteroids administered to treat evolving bronchopulmonary dysplasia on oxygen diffusion and ventilation efficiency. This was a retrospective cohort study of ventilated infants who received a 9-day course of dexamethasone in a tertiary neonatal unit. We calculated the transcutaneous oxygen saturation-to-fraction of inspired oxygen (F Seventy infants (38 males) with a median gestational age (GA) of 25.0 weeks (IQR, 24.3-26.0 weeks) and a median birth weight of 0.70 kg (IQR, 0.63-0.82 kg) were studied at a median postnatal age of 39 days (IQR, 29-48 days). The median SFR before treatment was 1.42 (IQR, 1.19-1.72), and the highest SFR was 2.35 (IQR, 1.87-2.83) after 9 days of treatment. The median V Oxygen diffusion continues to improve throughout the entire duration of a 9-day course of systemically administered corticosteroids in ventilated extremely preterm infants. More immature infants are less responsive to corticosteroids.
Identifiants
pubmed: 31500862
pii: S0022-3476(19)30970-9
doi: 10.1016/j.jpeds.2019.07.062
pii:
doi:
Substances chimiques
Glucocorticoids
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-23Subventions
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.