Comparison of pulsed and oscillating gradient diffusion-weighted MRI for characterizing hepatocellular nodules in liver cirrhosis: ex vivo study in a rat model.
diffusion-weighted MR imaging
dysplastic nodule
hepatocellular carcinoma
liver cirrhosis
oscillating gradient diffusion-weighted MR imaging
regenerative nodule
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
18
04
2019
accepted:
07
08
2019
pubmed:
12
9
2019
medline:
20
5
2021
entrez:
12
9
2019
Statut:
ppublish
Résumé
In contrast to classical pulsed gradient diffusion-weighted MRI, oscillating gradient diffusion-weighted MR imaging (DWI) is sensitive to short distance diffusion changes at the intracellular level. To compare the diagnostic performance of pulsed and oscillating DWI for characterizing hepatocellular nodules in a rat model of hepatic cirrhosis. Prospective, experimental study. Cirrhosis was induced by weekly intraperitoneal injection of diethylnitrosamine in Wistar rats. Ex vivo liver MRI was performed at 7T with T Apparent diffusion coefficient from pulsed (ADC Differences between groups were assessed with Kruskal-Wallis and Mann-Whitney tests. ADC, mainly ADC ADC during hepatocarcinogenesis in rats increased in nodules with intermediate malignancy and decreased in progressed hepatocellular carcinomas. Our results suggest that oscillating gradient DWI is more sensitive to the early steps of hepatocarcinogenesis and might be useful for differentiating between high-grade dysplastic nodules / early hepatocellular carcinomas and regenerating nodules / low-grade dysplastic nodules. 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:1065-1074.
Sections du résumé
BACKGROUND
In contrast to classical pulsed gradient diffusion-weighted MRI, oscillating gradient diffusion-weighted MR imaging (DWI) is sensitive to short distance diffusion changes at the intracellular level.
PURPOSE
To compare the diagnostic performance of pulsed and oscillating DWI for characterizing hepatocellular nodules in a rat model of hepatic cirrhosis.
STUDY TYPE
Prospective, experimental study.
ANIMAL MODEL
Cirrhosis was induced by weekly intraperitoneal injection of diethylnitrosamine in Wistar rats.
FIELD STRENGTH/SEQUENCE
Ex vivo liver MRI was performed at 7T with T
ASSESSMENT
Apparent diffusion coefficient from pulsed (ADC
STATISTICAL TESTS
Differences between groups were assessed with Kruskal-Wallis and Mann-Whitney tests.
RESULTS
ADC, mainly ADC
DATA CONCLUSION
ADC during hepatocarcinogenesis in rats increased in nodules with intermediate malignancy and decreased in progressed hepatocellular carcinomas. Our results suggest that oscillating gradient DWI is more sensitive to the early steps of hepatocarcinogenesis and might be useful for differentiating between high-grade dysplastic nodules / early hepatocellular carcinomas and regenerating nodules / low-grade dysplastic nodules.
LEVEL OF EVIDENCE
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2020;51:1065-1074.
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1065-1074Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
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