Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy.
Animals
Cells, Cultured
Cytokines
/ metabolism
Diabetic Nephropathies
/ drug therapy
Dipeptides
/ pharmacology
Epithelial-Mesenchymal Transition
Growth Hormone
/ pharmacology
Humans
Male
Mice
Podocytes
/ drug effects
Proteinuria
/ drug therapy
Receptor, Notch1
/ antagonists & inhibitors
Signal Transduction
Notch pathway
diabetic nephropathy
fibrosis
growth hormone
podocyte
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
19
04
2019
revised:
28
08
2019
pubmed:
13
9
2019
medline:
13
6
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
Growth hormone (GH) plays a significant role in normal renal function and overactive GH signaling has been implicated in proteinuria in diabetes and acromegaly. Previous results have shown that the glomerular podocytes, which play an essential role in renal filtration, express the GH receptor, suggesting the direct action of GH on these cells. However, the exact mechanism and the downstream pathways by which excess GH leads to diabetic nephropathy is not established. In the present article, using immortalized human podocytes
Identifiants
pubmed: 31511328
pii: S0021-9258(20)30467-1
doi: 10.1074/jbc.RA119.008966
pmc: PMC6827306
doi:
Substances chimiques
Cytokines
0
Dipeptides
0
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester
0
NOTCH1 protein, human
0
Receptor, Notch1
0
Growth Hormone
9002-72-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16109-16122Informations de copyright
© 2019 Nishad et al.
Références
Kidney Int. 2006 Jun;69(11):2101-6
pubmed: 16625147
J Exp Med. 2007 Nov 26;204(12):2935-48
pubmed: 17984306
J Cell Physiol. 2019 May;234(5):6503-6518
pubmed: 30238984
Development. 2003 Oct;130(20):5031-42
pubmed: 12952904
Cytokine Growth Factor Rev. 2011 Jun;22(3):131-9
pubmed: 21757394
Diabetes. 2015 Dec;64(12):4099-111
pubmed: 26293507
Development. 2017 Dec 15;144(24):4530-4539
pubmed: 29113990
Front Med (Lausanne). 2017 Jul 12;4:102
pubmed: 28748185
Development. 2008 Feb;135(3):411-24
pubmed: 18192283
EMBO J. 2004 Mar 10;23(5):1155-65
pubmed: 14976548
Clin Exp Nephrol. 2017 Feb;21(1):1-6
pubmed: 26894604
Nat Rev Nephrol. 2011 Oct 18;7(12):684-96
pubmed: 22009250
J Cell Biochem. 2015 Sep;116(9):1947-56
pubmed: 25740786
Mol Biol Cell. 2011 Dec;22(24):4750-64
pubmed: 22031288
Curr Opin Nephrol Hypertens. 2019 Jan;28(1):10-15
pubmed: 30394899
Stem Cells. 2010 Sep;28(9):1674-85
pubmed: 20680961
Kidney Int. 2010 Sep;78(5):514-22
pubmed: 20531454
J Mol Biol. 2008 Feb 8;376(1):131-40
pubmed: 18155729
J Biol Chem. 2010 Oct 8;285(41):31148-56
pubmed: 20682777
FASEB J. 2006 May;20(7):1009-11
pubmed: 16571776
Development. 2007 Feb;134(3):535-44
pubmed: 17215306
Nephron Exp Nephrol. 2009;111(4):e73-9
pubmed: 19293596
Immunopharmacol Immunotoxicol. 2016;38(1):39-49
pubmed: 26849902
J Biol Chem. 2007 Apr 20;282(16):11969-81
pubmed: 17317671
Chin J Cancer. 2011 Sep;30(9):603-11
pubmed: 21880181
Kidney Int. 2005 Nov;68(5):1951-2
pubmed: 16221173
J Cell Biochem. 2018 Nov 1;:null
pubmed: 30387200
J Biol Chem. 2017 Oct 6;292(40):16491-16497
pubmed: 28842487
Biol Sex Differ. 2013 Jun 27;4:12
pubmed: 23805912
Sci Rep. 2017 Aug 29;7(1):9833
pubmed: 28852159
EMBO Rep. 2002 Jul;3(7):688-94
pubmed: 12101103
Ren Fail. 2017 Nov;39(1):474-483
pubmed: 28413908
Curr Opin Nephrol Hypertens. 2003 Jan;12(1):5-10
pubmed: 12496659
N Engl J Med. 1984 Mar 29;310(13):810-5
pubmed: 6700669
Toxicol Sci. 2004 Nov;82(1):341-58
pubmed: 15319485
Am J Kidney Dis. 1992 Jul;20(1):1-17
pubmed: 1621674
Biochim Biophys Acta. 2008 Jan;1782(1):10-21
pubmed: 17980714
Fibrogenesis Tissue Repair. 2014 May 30;7:9
pubmed: 24917887
J Am Soc Nephrol. 2008 Jun;19(6):1139-57
pubmed: 18337488
Breast Cancer Res. 2007;9(3):105
pubmed: 17531087
J Clin Invest. 2010 Nov;120(11):4040-54
pubmed: 20978353
Diabetes. 2010 Aug;59(8):1865-7
pubmed: 20668292
Development. 2007 Feb;134(4):801-11
pubmed: 17229764
Diabetes. 2010 Aug;59(8):1915-25
pubmed: 20522599
Dev Cell. 2013 Jun 24;25(6):585-98
pubmed: 23806616
Nat Med. 2008 Mar;14(3):290-8
pubmed: 18311147
Curr Diabetes Rev. 2011 Jan;7(1):50-5
pubmed: 21067510
Cell Mol Life Sci. 2008 May;65(9):1311-34
pubmed: 18239854