Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells.
Apoptosis
/ drug effects
Breast Neoplasms
/ genetics
DNA, Neoplasm
/ metabolism
Delta-5 Fatty Acid Desaturase
Dexamethasone
/ pharmacology
Endoplasmic Reticulum Stress
/ drug effects
Endoribonucleases
/ metabolism
Estrogens
/ pharmacology
Female
Gene Expression Regulation, Neoplastic
/ drug effects
Humans
Inflammation
/ pathology
MCF-7 Cells
NF-kappa B
/ metabolism
Phosphatidylinositol 3-Kinases
/ metabolism
Protein Binding
/ drug effects
Protein Serine-Threonine Kinases
/ metabolism
Proteolysis
/ drug effects
Receptors, Glucocorticoid
/ metabolism
Signal Transduction
/ drug effects
Tumor Necrosis Factor-alpha
/ metabolism
eIF-2 Kinase
/ metabolism
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
12
12
2018
revised:
26
04
2019
accepted:
01
07
2019
pubmed:
13
9
2019
medline:
10
6
2020
entrez:
13
9
2019
Statut:
ppublish
Résumé
Our clinically relevant finding is that glucocorticoids block estrogen (E
Identifiants
pubmed: 31511352
pii: 1535-7163.MCT-18-1363
doi: 10.1158/1535-7163.MCT-18-1363
pmc: PMC6774891
mid: NIHMS1533927
doi:
Substances chimiques
DNA, Neoplasm
0
Delta-5 Fatty Acid Desaturase
0
Estrogens
0
NF-kappa B
0
Receptors, Glucocorticoid
0
Tumor Necrosis Factor-alpha
0
Dexamethasone
7S5I7G3JQL
FADS1 protein, human
EC 1.14.19.3
EIF2AK3 protein, human
EC 2.7.11.1
ERN1 protein, human
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
eIF-2 Kinase
EC 2.7.11.1
Endoribonucleases
EC 3.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1684-1695Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
Références
Br J Cancer. 1996 Oct;74(8):1227-36
pubmed: 8883409
Cancer Res. 2014 Dec 1;74(23):7060-8
pubmed: 25304262
Proc Natl Acad Sci U S A. 2013 May 21;110(21):8708-13
pubmed: 23650397
Nature. 2008 Jul 24;454(7203):455-62
pubmed: 18650916
Arch Biochem Biophys. 2018 May 15;646:98-106
pubmed: 29625124
Mol Cell Endocrinol. 2013 Nov 5;380(1-2):41-54
pubmed: 23267834
JAMA. 2009 Aug 19;302(7):774-80
pubmed: 19690310
Cancer Res. 2013 Jul 15;73(14):4510-20
pubmed: 23704208
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1500-E1508
pubmed: 28174265
JAMA. 2002 Jul 17;288(3):321-33
pubmed: 12117397
J Natl Cancer Inst. 2003 Nov 5;95(21):1586-97
pubmed: 14600091
Eur J Cancer. 2014 Jan;50(2):457-68
pubmed: 24183378
Int J Oncol. 2014 May;44(5):1529-38
pubmed: 24604139
Nature. 2008 Jun 5;453(7196):807-11
pubmed: 18432192
Lancet Oncol. 2012 May;13(5):476-86
pubmed: 22401913
Steroids. 2014 Nov;90:44-52
pubmed: 24930824
Nat Genet. 2006 Nov;38(11):1289-97
pubmed: 17013392
Cell. 1990 Sep 21;62(6):1205-15
pubmed: 2169352
J Clin Invest. 2017 Apr 3;127(4):1136-1145
pubmed: 28319043
N Engl J Med. 2005 Oct 20;353(16):1711-23
pubmed: 16236742
EMBO J. 2001 Aug 15;20(16):4380-90
pubmed: 11500365
Oncogene. 2003 Mar 13;22(10):1461-74
pubmed: 12629509
Oncogene. 2006 Oct 30;25(51):6868-86
pubmed: 17072333
Cell. 2016 Apr 21;165(3):593-605
pubmed: 27062924
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18879-86
pubmed: 22011582
J Clin Pharmacol. 2017 May;57(5):627-639
pubmed: 28074489
Clin Cancer Res. 2000 May;6(5):2028-36
pubmed: 10815929
Trends Immunol. 2007 Dec;28(12):551-8
pubmed: 17981503
Trends Pharmacol Sci. 2013 Sep;34(9):518-30
pubmed: 23953592
J Biol Chem. 2013 Aug 16;288(33):24020-34
pubmed: 23814048
Cell Death Dis. 2018 Aug 13;9(8):842
pubmed: 30104654
Cell. 1990 Sep 21;62(6):1189-204
pubmed: 2169351
J Natl Cancer Inst. 2001 Nov 21;93(22):1714-23
pubmed: 11717332
Mol Cancer Res. 2015 Oct;13(10):1367-76
pubmed: 26116171
Mol Cell Endocrinol. 2011 Jul 4;340(2):127-36
pubmed: 21605624
Cells. 2013 Mar 26;2(2):202-23
pubmed: 24709697
Endocr Relat Cancer. 2018 Feb;25(2):R83-R113
pubmed: 29162647
Immunity. 2017 Aug 15;47(2):298-309.e5
pubmed: 28801231
J Natl Cancer Inst. 2005 Dec 7;97(23):1746-59
pubmed: 16333030
J Clin Invest. 2012 Jun;122(6):2130-40
pubmed: 22585571
Mol Cancer Ther. 2018 Dec;17(12):2732-2745
pubmed: 30224430
Nature. 2009 Nov 5;462(7269):58-64
pubmed: 19890323
Nucleic Acids Res. 2017 Aug 21;45(14):8596-8608
pubmed: 28591827
Steroids. 2007 Jan;72(1):7-25
pubmed: 17169390
Cancer Res. 2013 Aug 15;73(16):5130-9
pubmed: 23803465
Curr Opin Pharmacol. 2010 Aug;10(4):497-504
pubmed: 20493772
Mol Cell. 2006 Feb 17;21(4):555-64
pubmed: 16483936
J Immunol. 2013 Jul 1;191(1):424-33
pubmed: 23729444
Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E971-9
pubmed: 12376324
Cell Death Discov. 2018 Feb 12;4:15
pubmed: 29531812
Horm Mol Biol Clin Investig. 2012 Feb;9(2):143-163
pubmed: 23308083
Mol Endocrinol. 2011 Apr;25(4):564-74
pubmed: 21330404
Mol Cell Biol. 1995 Feb;15(2):943-53
pubmed: 7823959