Origins of DNA replication.


Journal

PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074

Informations de publication

Date de publication:
09 2019
Historique:
entrez: 13 9 2019
pubmed: 13 9 2019
medline: 23 2 2020
Statut: epublish

Résumé

In all kingdoms of life, DNA is used to encode hereditary information. Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes. DNA synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. Here, we discuss commonalities and differences in replication origin organization and recognition in the three domains of life.

Identifiants

pubmed: 31513569
doi: 10.1371/journal.pgen.1008320
pii: PGENETICS-D-19-01197
pmc: PMC6742236
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1008320

Commentaires et corrections

Type : ErratumIn

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

Babatunde Ekundayo (B)

Quantitative Biology, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

Franziska Bleichert (F)

Quantitative Biology, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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Classifications MeSH