Computer-assisted cognitive remediation therapy for patients with schizophrenia induces microstructural changes in cerebellar regions involved in cognitive functions.
Adult
Cerebellum
/ diagnostic imaging
Cognition
/ physiology
Cognitive Dysfunction
/ diagnostic imaging
Cognitive Remediation
/ methods
Diffusion Magnetic Resonance Imaging
/ methods
Diffusion Tensor Imaging
/ methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neuropsychological Tests
Schizophrenia
/ diagnostic imaging
Schizophrenic Psychology
Therapy, Computer-Assisted
/ methods
Computer-assisted treatment
Diffusion tensor imaging (DTI)
Executive function
Japanese cognitive rehabilitation program for schizophrenia (Jcores)
Vocational cognitive ability training by jcores (VCAT-J)
White matter
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 10 2019
30 10 2019
Historique:
received:
13
04
2019
revised:
03
07
2019
accepted:
05
09
2019
pubmed:
16
9
2019
medline:
9
4
2020
entrez:
16
9
2019
Statut:
ppublish
Résumé
Previous studies have reported that cognitive remediation therapy (CRT) improves cognitive deficits in patents with schizophrenia. However, few studies have focused on the underlying structural alterations in the brain following Vocational Cognitive Ability Training by the Japanese Cognitive Rehabilitation Program for Schizophrenia (VCAT-J). In this study, we analyzed changes in diffusion tensor imaging parameters in 31 patients with schizophrenia after 12 weeks of intervention consisting of standard treatment alone or standard treatment plus VCAT-J, in order to determine the effect of the latter on white matter microstructural plasticity. Cognitive function was evaluated using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J) scale. The CRT group exhibited significant improvements in verbal fluency and composite BACS-J scores, relative to the treatment-as-usual (TAU) group. In addition, the CRT group exhibited significantly increased fractional anisotropy (FA) values, along with significantly decreased radial (RD) and mean diffusivity (MD) values, in the posterior lobe of the left cerebellum. Changes in RD and MD values were negatively correlated with changes in BACS-J composite scores. These suggest that VCAT-J might mediate improvements in myelin sheath composition in the posterior lobe of the left cerebellum, which may have been associated with improvements in cognitive function.
Identifiants
pubmed: 31521942
pii: S0925-4927(19)30111-8
doi: 10.1016/j.pscychresns.2019.09.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-46Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.