The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
Cell Line, Tumor
Cell Proliferation
/ genetics
Cyclin-Dependent Kinase Inhibitor p21
/ genetics
DNA-Activated Protein Kinase
/ metabolism
DNA-Binding Proteins
/ metabolism
Genes, Tumor Suppressor
/ physiology
Glioblastoma
/ genetics
Humans
MicroRNAs
/ genetics
Nerve Tissue Proteins
/ metabolism
S Phase Cell Cycle Checkpoints
/ physiology
Transcription Factors
/ metabolism
DNAPK
Glioblastoma
MYT1L
cell proliferation
miR-141
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
pubmed:
17
9
2019
medline:
4
9
2020
entrez:
17
9
2019
Statut:
ppublish
Résumé
Glioblastoma is the most aggressive brain tumor. Although miR-141 has been demonstrated to primarily function as a tumor suppressor in numerous malignancies, including glioblastoma, the mechanisms involved remain poorly understood. Here, it is shown that miR-141 is downregulated in glioblastoma cell lines and tissues and may exert its biological function via directly targeting
Identifiants
pubmed: 31522595
doi: 10.1080/15384101.2019.1652033
pmc: PMC6791708
doi:
Substances chimiques
CDKN1A protein, human
0
Cyclin-Dependent Kinase Inhibitor p21
0
DNA-Binding Proteins
0
MIRN141 microRNA, human
0
MYT1 protein, human
0
MYT1L protein, human
0
MicroRNAs
0
Nerve Tissue Proteins
0
Transcription Factors
0
DNA-Activated Protein Kinase
EC 2.7.11.1
PRKDC protein, human
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2876-2892Références
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