Illuminating the virus life cycle with single-molecule FRET imaging.
Conformational dynamics
Envelope glycoproteins
Genome packaging
Reverse transcriptase
Single-molecule FRET
Structure
Virus assembly
Virus entry
Virus life cycle
Journal
Advances in virus research
ISSN: 1557-8399
Titre abrégé: Adv Virus Res
Pays: United States
ID NLM: 0370441
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
17
9
2019
pubmed:
17
9
2019
medline:
31
12
2019
Statut:
ppublish
Résumé
Single-molecule Förster resonance energy transfer (smFRET) imaging has emerged as a powerful tool to probe conformational dynamics of viral proteins, identify novel structural intermediates that are hiding in averaging population-based measurements, permit access to the energetics of transitions and as such to the precise molecular mechanisms of viral replication. One strength of smFRET is the capability of characterizing biological molecules in their fully hydrated/native state, which are not necessarily available to other structural methods. Elegant experimental design for physiologically relevant conditions, such as intact virions, has permitted the detection of previously unknown conformational states of viral glycoproteins, revealed asymmetric intermediates, and allowed access to the real-time imaging of conformational changes during viral fusion. As more laboratories are applying smFRET, our understanding of the molecular mechanisms and the dynamic nature of viral proteins throughout the virus life cycle are predicted to improve and assist the development of novel antiviral therapies and vaccine design.
Identifiants
pubmed: 31522706
pii: S0065-3527(19)30021-1
doi: 10.1016/bs.aivir.2019.07.004
pmc: PMC7246055
mid: NIHMS1589942
pii:
doi:
Substances chimiques
env Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-273Subventions
Organisme : NIAID NIH HHS
ID : P01 AI150471
Pays : United States
Organisme : NIAID NIH HHS
ID : P50 AI150464
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM116654
Pays : United States
Informations de copyright
© 2019 Elsevier Inc. All rights reserved.
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