Association between anti-thyroid antibodies and negative symptoms in early psychosis.
Adolescent
Adult
Autoantibodies
/ blood
Autoantigens
/ immunology
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Iodide Peroxidase
/ immunology
Iron-Binding Proteins
/ immunology
Male
Psychotic Disorders
/ blood
Social Interaction
Thyroglobulin
/ immunology
Thyroid Gland
/ immunology
Thyrotropin
/ blood
Thyroxine
/ blood
Young Adult
autoimmune
psychopathology
psychosis
schizophrenia
thyroid
Journal
Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
25
01
2019
revised:
13
07
2019
accepted:
25
08
2019
pubmed:
19
9
2019
medline:
7
2
2021
entrez:
19
9
2019
Statut:
ppublish
Résumé
In the current cross-sectional study, we aimed to explore whether thyroid function or thyroid autoimmunity are associated with psychopathological symptoms and social functioning in patients with early psychosis. We hypothesized that psychopathological severity is greater in those patients with positive thyroid autoimmunity. We studied 70 outpatients with early psychosis (<3 years of illness) and 37 healthy subjects. Psychopathological symptoms (positive, negative, disorganized, excited and depressive) and social functioning were assessed. Thyroid autoimmunity (antibodies against thyroid peroxidase [TPO-Abs] and thyroglobulin [TG-Abs]) and thyroid function (thyroid-stimulating hormone [TSH] and free thyroxin [FT4]) were determined. Associations of thyroid variables and psychometric measures were assessed with Spearman's correlations. Logistic regression was performed to explore the association between psychopathological symptoms and positive anti-thyroidal antibodies while adjusting for covariates. When compared to patients without thyroid antibodies, those with positive thyroid antibodies had more negative symptoms and poorer function (P < .05). Titres of TPO-Abs were significantly correlated with negative and depressive PANSS domains and poorer functioning. TG-Abs were also associated with poorer functioning but not with psychopathological symptoms. TSH and FT4 concentrations were not associated with clinical symptoms. In the logistic regression analysis adjusted for age, gender, antipsychotic treatment, lithium, TSH and FT4 concentrations, negative symptoms were associated with thyroid autoimmunity (OR = 1.2, P = .019). Our study suggests that anti-thyroid antibodies are associated with a more severe phenotype with increased negative symptoms and poorer functioning in early psychotic patients. Since causality cannot be inferred with cross-sectional data, future longitudinal studies are needed to overcome this limitation.
Substances chimiques
Autoantibodies
0
Autoantigens
0
Iron-Binding Proteins
0
Thyrotropin
9002-71-5
Thyroglobulin
9010-34-8
TPO protein, human
EC 1.11.1.7
Iodide Peroxidase
EC 1.11.1.8
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
470-475Subventions
Organisme : Fundació la Marató de TV3
ID : 092230
Pays : International
Organisme : Fundació la Marató de TV3
ID : 092231
Pays : International
Organisme : Health Department of the Generalitat de Catalunya
ID : SLT006/17/00012
Pays : International
Organisme : Health Department of the Generalitat de Catalunya
ID : SLT008/18/00074
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI10/01607
Pays : International
Informations de copyright
© 2019 John Wiley & Sons Australia, Ltd.
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