Presenilin-1 Established ER-Ca
Animals
Anthracenes
/ pharmacology
Calcium
/ metabolism
Cell Line
Cell Membrane
/ drug effects
Endoplasmic Reticulum
/ drug effects
Glucose
/ pharmacology
Humans
Insulin Secretion
/ drug effects
Insulin-Secreting Cells
/ drug effects
Islets of Langerhans
/ drug effects
MAP Kinase Kinase 4
/ antagonists & inhibitors
Male
Mice
Mice, Inbred C57BL
Mitochondria
/ drug effects
Presenilin-1
/ metabolism
Ca2+ spiking
Endoplasmic reticulum
Insulin secretion
Mitochondria
Journal
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
ISSN: 1421-9778
Titre abrégé: Cell Physiol Biochem
Pays: Germany
ID NLM: 9113221
Informations de publication
Date de publication:
2019
2019
Historique:
accepted:
12
09
2019
entrez:
19
9
2019
pubmed:
19
9
2019
medline:
4
12
2019
Statut:
ppublish
Résumé
In our recent work, the importance of GSK3β-mediated phosphorylation of presenilin-1 as crucial process to establish a Ca Freshly isolated pancreatic islets and the two pancreatic β-cell lines INS-1 and MIN-6 were used. Cytosolic Ca Our data strengthened our previous findings of the existence of a presenilin-1-mediated ER-Ca These data complement our previous work and demonstrate that the sensitivity of pancreatic islets and β-cells to glucose illustrated as glucose-triggered cytosolic Ca
Sections du résumé
BACKGROUND/AIMS
In our recent work, the importance of GSK3β-mediated phosphorylation of presenilin-1 as crucial process to establish a Ca
METHODS
Freshly isolated pancreatic islets and the two pancreatic β-cell lines INS-1 and MIN-6 were used. Cytosolic Ca
RESULTS
Our data strengthened our previous findings of the existence of a presenilin-1-mediated ER-Ca
CONCLUSION
These data complement our previous work and demonstrate that the sensitivity of pancreatic islets and β-cells to glucose illustrated as glucose-triggered cytosolic Ca
Substances chimiques
Anthracenes
0
Presenilin-1
0
pyrazolanthrone
1TW30Y2766
MAP Kinase Kinase 4
EC 2.7.12.2
Glucose
IY9XDZ35W2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
573-586Subventions
Organisme : Austrian Science Funds (FWF)
ID : W1226-B18, P28529-B27, I3716-B27, P28854
Pays : International
Organisme : Austrian Research Society (FFG)
ID : 864690
Pays : International
Organisme : Austrian Science Fund FWF
ID : W 1226
Pays : Austria
Organisme : National Natural Science Foundation
ID : 31450110123
Pays : International
Organisme : Austrian Science Fund FWF
ID : J 4205
Pays : Austria
Informations de copyright
© Copyright by the Author(s). Published by Cell Physiol Biochem Press.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.