Dexmedetomidine reduces norepinephrine requirements and preserves renal oxygenation and function in ovine septic acute kidney injury.

Acute Kidney Injury / blood Adrenergic alpha-2 Receptor Agonists / pharmacology Adrenergic alpha-Agonists / pharmacology Animals Cytokines / blood Dexmedetomidine / pharmacology Drug Evaluation, Preclinical Escherichia coli Hemodynamics / drug effects Kidney / drug effects Norepinephrine / pharmacology Oxygen / metabolism Sepsis / complications Sheep
acute kidney injury dexmedetomidine norepinephrine renal hypoperfusion renal hypoxia sepsis

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
11 2019
Historique:
received: 19 03 2019
revised: 10 06 2019
accepted: 14 06 2019
pubmed: 19 9 2019
medline: 21 10 2020
entrez: 19 9 2019
Statut: ppublish

Résumé

Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore vasopressor responsiveness, decrease the requirement for norepinephrine and attenuate medullary hypoxia in ovine gram-negative sepsis. Sheep were instrumented with pulmonary and renal artery flow probes, and laser Doppler and oxygen-sensing probes in the renal cortex and medulla. Conscious sheep received an infusion of live Escherichia coli for 30 hours. Eight sheep in each group were randomized to receive norepinephrine, norepinephrine with dexmedetomidine, dexmedetomidine alone or saline vehicle, from 24-30 hours of sepsis. Sepsis significantly reduced the average mean arterial pressure (84 to 67 mmHg), average renal medullary perfusion (1250 to 730 perfusion units), average medullary tissue pO

Identifiants

DOI: 10.1016/j.kint.2019.06.013 PMID: 31530477
pubmed: 31530477
pii: S0085-2538(19)30700-8
doi: 10.1016/j.kint.2019.06.013
pii:
doi:

Substances chimiques

Adrenergic alpha-2 Receptor Agonists 0
Adrenergic alpha-Agonists 0
Cytokines 0
Dexmedetomidine 67VB76HONO
Oxygen S88TT14065
Norepinephrine X4W3ENH1CV

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1150-1161

Informations de copyright

Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Yugeesh R Lankadeva (YR)

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.

Shuai Ma (S)

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia; Division of Nephrology, Shanghai Ninth People's Hospital, University School of Medicine, Shanghai, China.

Naoya Iguchi (N)

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.

Roger G Evans (RG)

Cardiovascular Disease Program, Biomedicine Discovery Institute and Department of Physiology, Monash University, Victoria, Australia.

Sally G Hood (SG)

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.

David G S Farmer (DGS)

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia.

Simon R Bailey (SR)

Faculty of Veterinary Science, University of Melbourne, Victoria, Australia.

Rinaldo Bellomo (R)

Centre of Integrated Critical Care, School of Medicine, University of Melbourne, Melbourne, Victoria, Australia.

Clive N May (CN)

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia. Electronic address: clive.may@florey.edu.au.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes alpha-adrénergiques › Agonistes des récepteurs alpha-2 adrénergiques › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes alpha-adrénergiques › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Eucaryotes › Animaux › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Dexmédétomidine › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Norépinéphrine › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Dexmedetomidine reduces norepinephrine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Dexmedetomidine reduces norepinephrine...