FPR1 is the plague receptor on host immune cells.
Alleles
Animals
Antigens, Bacterial
/ metabolism
Bacterial Adhesion
CRISPR-Cas Systems
Chemotaxis
/ immunology
Disease Models, Animal
Female
HEK293 Cells
Humans
Macrophages
/ cytology
Male
Mice
Mice, Inbred C57BL
Neutrophils
/ cytology
Plague
/ immunology
Polymorphism, Single Nucleotide
/ genetics
Pore Forming Cytotoxic Proteins
/ metabolism
Receptors, Formyl Peptide
/ antagonists & inhibitors
Type III Secretion Systems
/ drug effects
U937 Cells
Yersinia pestis
/ chemistry
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
12
10
2018
accepted:
14
08
2019
pubmed:
20
9
2019
medline:
13
11
2019
entrez:
20
9
2019
Statut:
ppublish
Résumé
The causative agent of plague, Yersinia pestis, uses a type III secretion system to selectively destroy immune cells in humans, thus enabling Y. pestis to reproduce in the bloodstream and be transmitted to new hosts through fleabites. The host factors that are responsible for the selective destruction of immune cells by plague bacteria are unknown. Here we show that LcrV, the needle cap protein of the Y. pestis type III secretion system, binds to the N-formylpeptide receptor (FPR1) on human immune cells to promote the translocation of bacterial effectors. Plague infection in mice is characterized by high mortality; however, Fpr1-deficient mice have increased survival and antibody responses that are protective against plague. We identified FPR1
Identifiants
pubmed: 31534221
doi: 10.1038/s41586-019-1570-z
pii: 10.1038/s41586-019-1570-z
pmc: PMC6776691
mid: NIHMS1537547
doi:
Substances chimiques
Antigens, Bacterial
0
FPR1 protein, human
0
Fpr1 protein, mouse
0
LcrV protein, Yersinia
0
Pore Forming Cytotoxic Proteins
0
Receptors, Formyl Peptide
0
Type III Secretion Systems
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-62Subventions
Organisme : NIAID NIH HHS
ID : R01 AI042797
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI107792
Pays : United States
Organisme : NIAID NIH HHS
ID : U54 AI057153
Pays : United States
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