Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.
deletion
gene cluster
male fertility
semen
seminal vesicle proteins
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2019
14 Sep 2019
Historique:
received:
30
07
2019
revised:
11
09
2019
accepted:
12
09
2019
entrez:
22
9
2019
pubmed:
22
9
2019
medline:
7
2
2020
Statut:
epublish
Résumé
Multiple genes, whose functions or expression are overlapping, compensate for the loss of one gene. A gene cluster in the mouse genome encodes five seminal vesicle proteins (SVS2, SVS3, SVS4, SVS5, and SVS6). These proteins are produced by male rodents and function in formation of the copulatory plug following mating. SVS2 plays an essential role in the successful internal fertilization by protecting the sperm membrane against a uterine immune attack. We hypothesized that the four remaining seminal vesicle proteins (SVPs) of this gene cluster may partially/completely compensate for the deficiency of SVS2. For confirming our hypothesis, we generated mice lacking the entire SVP-encoding gene cluster and compared their fecundity with
Identifiants
pubmed: 31540031
pii: ijms20184557
doi: 10.3390/ijms20184557
pmc: PMC6769479
pii:
doi:
Substances chimiques
SVS2 protein, mouse
0
SVS4 protein, mouse
0
Seminal Vesicle Secretory Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K06474
Organisme : Japan Society for the Promotion of Science
ID : 17K18164
Organisme : Japan Agency for Medical Research and Development
ID : 17930555
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