Creatine transporter knockout mice (Slc6a8) show increases in serotonin-related proteins and are resilient to learned helplessness.
Animals
Anxiety
/ metabolism
Behavior, Animal
/ physiology
Corpus Striatum
/ metabolism
Creatine
/ metabolism
Depression
/ metabolism
Disease Models, Animal
Energy Metabolism
/ physiology
Female
Helplessness, Learned
Hippocampus
/ metabolism
Male
Membrane Transport Proteins
/ deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Resilience, Psychological
Serotonin
/ metabolism
Affective disorders
Anxiety
Depression
Energy metabolism
Journal
Behavioural brain research
ISSN: 1872-7549
Titre abrégé: Behav Brain Res
Pays: Netherlands
ID NLM: 8004872
Informations de publication
Date de publication:
13 01 2020
13 01 2020
Historique:
received:
08
07
2019
revised:
17
09
2019
accepted:
18
09
2019
pubmed:
23
9
2019
medline:
24
4
2021
entrez:
23
9
2019
Statut:
ppublish
Résumé
Approximately 20% of adults in the U.S. will experience an affective disorder during their life. While it is well established that serotonin (5-HT) is a crucial factor in mood, impaired cellular bioenergetics are also implicated. Creatine (Cr), through the Cr/Phospho-Cr (PCr) shuttle, maintains high ATP concentrations in the neuron. This system may be implicated in the etiology of affective disorders, as reduced Cr, PCr, and ATP are often seen in the brains of affected patients. To address this issue, Cr transporter (Crt) deficient male mice (Slc6a8
Identifiants
pubmed: 31542396
pii: S0166-4328(19)31060-5
doi: 10.1016/j.bbr.2019.112254
pii:
doi:
Substances chimiques
Membrane Transport Proteins
0
creatine transporter
0
Serotonin
333DO1RDJY
Creatine
MU72812GK0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112254Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.