UV-responsive cyclic peptide progelator bioinks.
Journal
Faraday discussions
ISSN: 1364-5498
Titre abrégé: Faraday Discuss
Pays: England
ID NLM: 9212301
Informations de publication
Date de publication:
30 10 2019
30 10 2019
Historique:
pubmed:
25
9
2019
medline:
27
5
2020
entrez:
25
9
2019
Statut:
ppublish
Résumé
We describe cyclic peptide progelators which cleave in response to UV light to generate linearized peptides which then self-assemble into gel networks. Cyclic peptide progelators were synthesized, where the peptides were sterically constrained, but upon UV irradiation, predictable cleavage products were generated. Amino acid sequences and formulation conditions were altered to tune the mechanical properties of the resulting gels. Characterization of the resulting morphologies and chemistry was achieved through liquid phase and standard TEM methods, combined with matrix assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS).
Identifiants
pubmed: 31549115
doi: 10.1039/c9fd00026g
pmc: PMC7363176
mid: NIHMS1604928
doi:
Substances chimiques
Biocompatible Materials
0
Gels
0
Peptides, Cyclic
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-57Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL117326
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139001
Pays : United States
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