Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study.
Adult
Female
Gestational Age
Humans
India
Infant, Newborn
Injections, Intramuscular
Isoxsuprine
/ administration & dosage
Obstetric Labor, Premature
/ drug therapy
Pregnancy
Pregnancy Outcome
Premature Birth
/ prevention & control
Prospective Studies
Tachycardia
/ chemically induced
Tocolysis
/ methods
Tocolytic Agents
/ administration & dosage
Vomiting
/ chemically induced
Young Adult
Journal
American journal of perinatology
ISSN: 1098-8785
Titre abrégé: Am J Perinatol
Pays: United States
ID NLM: 8405212
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
25
9
2019
medline:
12
10
2021
entrez:
25
9
2019
Statut:
ppublish
Résumé
The aim of the study is to obtain insights on the short and long-term safety and effectiveness of isoxsuprine hydrochloride as a tocolytic agent in the management of PTL. In this prospective, single-center, noncomparative study, patients (with preterm labor at gestational age of 24-37 weeks) were administered intravenous (IV) infusion of 40-mg isoxsuprine hydrochloride until uterine quiescence, followed by intramuscular (IM) injection of isoxsuprine hydrochloride 10 mg/4-hourly for first 24 hours and maintained with retard 40-mg sustained release capsule (two times a day) till the time of delivery or 37 completed weeks of pregnancy. All patients ( Isoxsuprine was found to be an effective and well-tolerated tocolytic agent in arresting PTL, in turn resulting in the overall improvement in maternal and perinatal outcomes.
Identifiants
pubmed: 31550735
doi: 10.1055/s-0039-1696720
doi:
Substances chimiques
Tocolytic Agents
0
Isoxsuprine
R15UI3245N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
291-295Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.