Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection.
Bacteria
/ classification
CD4-Positive T-Lymphocytes
/ chemistry
Computational Biology
/ methods
Female
Gene Expression Profiling
/ methods
Gene Regulatory Networks
Haemophilus influenzae
/ classification
Humans
Infant
Male
Microbiota
Nose
/ microbiology
RNA, Ribosomal, 16S
/ genetics
Respiratory Syncytial Virus Infections
/ genetics
Sequence Analysis, RNA
Severity of Illness Index
Software
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 09 2019
25 09 2019
Historique:
received:
27
09
2018
accepted:
09
09
2019
entrez:
27
9
2019
pubmed:
27
9
2019
medline:
30
10
2020
Statut:
epublish
Résumé
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood. Although risk factors for RSV infection have been identified, the role of microbial species in the respiratory tract is only partially known. We aimed to understand the impact of interactions between the nasal microbiome and host transcriptome on the severity and clinical outcomes of RSV infection. We used 16 S rRNA sequencing to characterize the nasal microbiome of infants with RSV infection. We used RNA sequencing to interrogate the transcriptome of CD4
Identifiants
pubmed: 31554845
doi: 10.1038/s41598-019-50217-w
pii: 10.1038/s41598-019-50217-w
pmc: PMC6761288
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
13824Subventions
Organisme : NCRR NIH HHS
ID : M01 RR000044
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002001
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201200005C
Pays : United States
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