Evolving principles underlying neural lineage conversion and their relevance for biomedical translation.

Cell Differentiation Cellular Reprogramming Embryonic Development Epigenesis, Genetic Transcription Factors
Cell programming Direct conversion Disease modelling Forward programming In vivo conversion Transdifferentiation Translation Transplantation

Journal

F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320

Informations de publication

Date de publication:
2019
Historique:
accepted: 23 08 2019
entrez: 28 9 2019
pubmed: 29 9 2019
medline: 29 10 2019
Statut: epublish

Résumé

Scientific and technological advances of the past decade have shed light on the mechanisms underlying cell fate acquisition, including its transcriptional and epigenetic regulation during embryonic development. This knowledge has enabled us to purposefully engineer cell fates

Identifiants

DOI: 10.12688/f1000research.18926.1 PMID: 31559012 PMC: PMC6743253
pubmed: 31559012
doi: 10.12688/f1000research.18926.1
pmc: PMC6743253
pii:
doi:

Substances chimiques

Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS100514
Pays : United States

Déclaration de conflit d'intérêts

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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Auteurs

Lea Jessica Flitsch (LJ)

Institute of Reconstructive Neurobiology, University of Bonn School of Medicine & University Hospital Bonn, Bonn, North Rhine Wesphalia, 53127, Germany.

Oliver Brüstle (O)

Institute of Reconstructive Neurobiology, University of Bonn School of Medicine & University Hospital Bonn, Bonn, North Rhine Wesphalia, 53127, Germany.
ORCID: 0000-0002-2746-6519

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Evolving principles underlying neural lineage...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › Evolving principles underlying neural lineage...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Evolving principles underlying neural lineage...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Evolving principles underlying neural lineage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Evolving principles underlying neural lineage...