Mendelian non-syndromic obesity.
Journal
Acta bio-medica : Atenei Parmensis
ISSN: 2531-6745
Titre abrégé: Acta Biomed
Pays: Italy
ID NLM: 101295064
Informations de publication
Date de publication:
30 09 2019
30 09 2019
Historique:
received:
06
08
2019
accepted:
06
08
2019
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
24
10
2020
Statut:
epublish
Résumé
Obesity is highly heritable and arises from the interplay of many genes and environmental factors. It can be defined as the result of prolonged imbalance between calorie intake and energy utilization. About 5% of cases of non-syndromic obesity are monogenic (Mendelian obesity). The amount of adipose tissue in the body is mainly regulated by leptin, a hormone produced by adipocytes, and Mendelian obesity is mainly caused by mutations that disrupt the leptin/melanocortin pathway. In this article, we summarize the genes involved in genetic obesity and the test we use for genetic analysis.
Identifiants
pubmed: 31577261
doi: 10.23750/abm.v90i10-S.8766
pmc: PMC7233639
doi:
Substances chimiques
Leptin
0
Melanocortins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-89Références
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