Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

ATP Binding Cassette Transporter, Subfamily G, Member 2 / genetics Cardiovascular Diseases / blood Cohort Studies Genetic Loci Genetic Markers Genetic Predisposition to Disease Genome-Wide Association Study Gout / blood Hepatocyte Nuclear Factor 1-alpha / genetics Hepatocyte Nuclear Factor 4 / genetics Humans Kidney / metabolism Liver / metabolism Metabolic Diseases / blood Neoplasm Proteins / genetics Organ Specificity Polymorphism, Single Nucleotide Signal Transduction Uric Acid / blood

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
10 2019
Historique:
received: 17 01 2019
accepted: 27 08 2019
pubmed: 4 10 2019
medline: 23 1 2020
entrez: 4 10 2019
Statut: ppublish

Résumé

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.

Identifiants

DOI: 10.1038/s41588-019-0504-x PMID: 31578528 PMC: PMC6858555
pubmed: 31578528
doi: 10.1038/s41588-019-0504-x
pii: 10.1038/s41588-019-0504-x
pmc: PMC6858555
mid: NIHMS1538428
doi:

Substances chimiques

ABCG2 protein, human 0
ATP Binding Cassette Transporter, Subfamily G, Member 2 0
Genetic Markers 0
HNF1A protein, human 0
HNF4A protein, human 0
Hepatocyte Nuclear Factor 1-alpha 0
Hepatocyte Nuclear Factor 4 0
Neoplasm Proteins 0
Uric Acid 268B43MJ25

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1459-1474

Subventions

Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U01 HL120393
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG002295
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073178
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL129982
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD043483
Pays : United States
Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK114091
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : P30 DK116074
Pays : United States

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Auteurs

Adrienne Tin (A)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. atin1@jhu.edu.
Welch Centre for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. atin1@jhu.edu.
ORCID: 0000-0002-4207-5866

Jonathan Marten (J)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-6916-2014

Victoria L Halperin Kuhns (VL)

Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Yong Li (Y)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-2651-8791

Matthias Wuttke (M)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-3420-5082

Holger Kirsten (H)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
ORCID: 0000-0002-3126-7950

Karsten B Sieber (KB)

Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.

Chengxiang Qiu (C)

Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-6346-8669

Mathias Gorski (M)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

Zhi Yu (Z)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Ayush Giri (A)

Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0002-7786-4670

Gardar Sveinbjornsson (G)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.

Man Li (M)

Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.
ORCID: 0000-0002-3839-0281

Audrey Y Chu (AY)

Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.

Anselm Hoppmann (A)

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.

Luke J O'Connor (LJ)

Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
ORCID: 0000-0003-2730-9668

Bram Prins (B)

Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.

Teresa Nutile (T)

Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy.

Damia Noce (D)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Masato Akiyama (M)

Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan.
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Massimiliano Cocca (M)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.

Sahar Ghasemi (S)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

Peter J van der Most (PJ)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-8450-3518

Katrin Horn (K)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
ORCID: 0000-0002-5307-6936

Yizhe Xu (Y)

Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA.

Christian Fuchsberger (C)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Sanaz Sedaghat (S)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Saima Afaq (S)

Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan.

Najaf Amin (N)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Johan Ärnlöv (J)

Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.
School of Health and Social Studies, Dalarna University, Falun, Sweden.

Stephan J L Bakker (SJL)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Nisha Bansal (N)

Division of Nephrology, University of Washington, Seattle, WA, USA.
Kidney Research Institute, University of Washington, Seattle, WA, USA.

Daniela Baptista (D)

Cardiology, Geneva University Hospitals, Geneva, Switzerland.

Sven Bergmann (S)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
ORCID: 0000-0002-6785-9034

Mary L Biggs (ML)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

Ginevra Biino (G)

Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
ORCID: 0000-0002-9936-946X

Eric Boerwinkle (E)

Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA.

Erwin P Bottinger (EP)

Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Thibaud S Boutin (TS)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Marco Brumat (M)

University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.
ORCID: 0000-0003-3268-039X

Ralph Burkhardt (R)

LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

Eric Campana (E)

University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.

Archie Campbell (A)

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0003-0198-5078

Harry Campbell (H)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Robert J Carroll (RJ)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Eulalia Catamo (E)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.

John C Chambers (JC)

Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Department of Cardiology, Ealing Hospital, London, UK.
Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.

Marina Ciullo (M)

Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy.
IRCCS Neuromed, Pozzilli, Italy.

Maria Pina Concas (MP)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
ORCID: 0000-0003-3598-2537

Josef Coresh (J)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
ORCID: 0000-0002-4598-0669

Tanguy Corre (T)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.

Daniele Cusi (D)

Institute of Biomedical Technologies, Italy National Research Council, Milano, Italy.
Bio4Dreams, Milano, Italy.

Sala Cinzia Felicita (SC)

San Raffaele Research Institute, Milano, Italy.
ORCID: 0000-0003-2514-2075

Martin H de Borst (MH)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-4127-8733

Alessandro De Grandi (A)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Renée de Mutsert (R)

Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.

Aiko P J de Vries (APJ)

Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.

Graciela Delgado (G)

Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Ayşe Demirkan (A)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands.

Olivier Devuyst (O)

Institute of Physiology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0003-3744-4767

Katalin Dittrich (K)

Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.

Kai-Uwe Eckardt (KU)

Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Georg Ehret (G)

Cardiology, Geneva University Hospitals, Geneva, Switzerland.
ORCID: 0000-0002-5730-0675

Karlhans Endlich (K)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0001-6052-6061

Michele K Evans (MK)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

Ron T Gansevoort (RT)

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Paolo Gasparini (P)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.

Vilmantas Giedraitis (V)

Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-3423-2021

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research, Neuherberg, Germany.

Giorgia Girotto (G)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.
University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy.
ORCID: 0000-0003-4507-6589

Martin Gögele (M)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Scott D Gordon (SD)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0001-7623-328X

Daniel F Gudbjartsson (DF)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
ORCID: 0000-0002-5222-9857

Vilmundur Gudnason (V)

Icelandic Heart Association, Kópavogur, Iceland.
Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0001-5696-0084

Toomas Haller (T)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Pavel Hamet (P)

Montreal University Hospital Research Centre, Centre Hospitalier de lUniversité de Montréal, Montreal, Quebec, Canada.
Medpharmgene, Montreal, Quebec, Canada.

Tamara B Harris (TB)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.

Caroline Hayward (C)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-9405-9550

Andrew A Hicks (AA)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.
ORCID: 0000-0001-6320-0411

Edith Hofer (E)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.

Hilma Holm (H)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.

Wei Huang (W)

Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Centre, Shanghai, China.
Shanghai Industrial Technology Institute, Shanghai, China.

Nina Hutri-Kähönen (N)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Shih-Jen Hwang (SJ)

National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
The Centre for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA.

M Arfan Ikram (MA)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ORCID: 0000-0003-0372-8585

Raychel M Lewis (RM)

Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Erik Ingelsson (E)

Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-2256-6972

Johanna Jakobsdottir (J)

Icelandic Heart Association, Kópavogur, Iceland.
The Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland.

Ingileif Jonsdottir (I)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
ORCID: 0000-0001-8339-150X

Helgi Jonsson (H)

Landspitalinn University Hospital, Reykjavík, Iceland.
University of Iceland, Reykjavík, Iceland.

Peter K Joshi (PK)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-6361-5059

Navya Shilpa Josyula (NS)

Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
ORCID: 0000-0003-2782-8812

Bettina Jung (B)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.

Mika Kähönen (M)

Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Yoichiro Kamatani (Y)

Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan.
Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
ORCID: 0000-0001-8748-5597

Masahiro Kanai (M)

Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-5165-4408

Shona M Kerr (SM)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

Wieland Kiess (W)

LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.

Marcus E Kleber (ME)

Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
ORCID: 0000-0003-0663-7275

Wolfgang Koenig (W)

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany.
ORCID: 0000-0002-2064-9603

Jaspal S Kooner (JS)

Department of Cardiology, Ealing Hospital, London, UK.
Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
MRC-PHE Centre for Environment and Health, 323 School of Public Health, Imperial College London, London, UK.
National Heart and Lung Institute, Imperial College London, London, UK.

Antje Körner (A)

LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany.
Centre for Pediatric Research, University of Leipzig, Leipzig, Germany.

Peter Kovacs (P)

Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany.
ORCID: 0000-0002-0290-5423

Bernhard K Krämer (BK)

Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Florian Kronenberg (F)

Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
ORCID: 0000-0003-2229-1120

Michiaki Kubo (M)

RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan.

Brigitte Kühnel (B)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.

Martina La Bianca (M)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.

Leslie A Lange (LA)

Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.

Benjamin Lehne (B)

Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Jun Liu (J)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0001-5288-3042

Markus Loeffler (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8532-5087

Leo-Pekka Lyytikäinen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
ORCID: 0000-0002-7200-5455

Reedik Magi (R)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Anubha Mahajan (A)

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
ORCID: 0000-0001-5585-3420

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-4069-8020

Winfried März (W)

Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.

Deborah Mascalzoni (D)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Koichi Matsuda (K)

Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

Christa Meisinger (C)

Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany.

Thomas Meitinger (T)

German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Institute of Human Genetics, Technische Universität München, Munich, Germany.

Andres Metspalu (A)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-3718-796X

Yuri Milaneschi (Y)

Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Christopher J O'Donnell (CJ)

VA Boston Healthcare System, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Otis D Wilson (OD)

Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA.

J Michael Gaziano (JM)

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.

Pashupati P Mishra (PP)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Karen L Mohlke (KL)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0001-6721-153X

Nina Mononen (N)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Grant W Montgomery (GW)

University of Queensland, St Lucia, Queensland, Australia.
ORCID: 0000-0002-4140-8139

Dennis O Mook-Kanamori (DO)

Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.
Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands.

Martina Müller-Nurasyid (M)

German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
ORCID: 0000-0003-3793-5910

Girish N Nadkarni (GN)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Mike A Nalls (MA)

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Data Tecnica International, Glen Echo, MD, USA.

Matthias Nauck (M)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.

Kjell Nikus (K)

Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Boting Ning (B)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Ilja M Nolte (IM)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-5047-4077

Raymond Noordam (R)

Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.

Jeffrey R O'Connell (JR)

University of Maryland School of Medicine, Baltimore, MD, USA.

Isleifur Olafsson (I)

Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.

Sandosh Padmanabhan (S)

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Brenda W J H Penninx (BWJH)

Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

Thomas Perls (T)

Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research, Neuherberg, Germany.
German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.

Mario Pirastu (M)

Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.

Nicola Pirastu (N)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-5363-3886

Giorgio Pistis (G)

Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.

Ozren Polasek (O)

Faculty of Medicine, University of Split, Split, Croatia.
Gen-info Ltd, Zagreb, Croatia.

Belen Ponte (B)

Nephrology Service, Department of Specialties in Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.

David J Porteous (DJ)

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

Tanja Poulain (T)

LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.

Michael H Preuss (MH)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-5266-8465

Ton J Rabelink (TJ)

Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, the Netherlands.

Laura M Raffield (LM)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0002-7892-193X

Olli T Raitakari (OT)

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Rainer Rettig (R)

Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.

Myriam Rheinberger (M)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.

Kenneth M Rice (KM)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-3071-7278

Federica Rizzi (F)

Department of Health Sciences, University of Milan, Milano, Italy.
ePhood Scientific Unit, ePhood SRL, Milano, Italy.
ORCID: 0000-0002-4606-6553

Antonietta Robino (A)

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy.

Igor Rudan (I)

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-6993-6884

Alena Krajcoviechova (A)

Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.
Thomayer Hospital, Prague, Czech Republic.

Renata Cifkova (R)

Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic.
Department of Medicine II, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Rico Rueedi (R)

Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Daniela Ruggiero (D)

Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy.
IRCCS Neuromed, Pozzilli, Italy.

Kathleen A Ryan (KA)

Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.

Yasaman Saba (Y)

Molecular Biology and Biochemistry, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.

Erika Salvi (E)

Department of Health Sciences, University of Milan, Milano, Italy.
Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Helena Schmidt (H)

Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.

Reinhold Schmidt (R)

Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.

Christian M Shaffer (CM)

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.

Albert V Smith (AV)

Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
ORCID: 0000-0003-1942-5845

Blair H Smith (BH)

Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.

Cassandra N Spracklen (CN)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0003-3590-7182

Konstantin Strauch (K)

Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.

Michael Stumvoll (M)

Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig, Germany.

Patrick Sulem (P)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
ORCID: 0000-0001-7123-6123

Salman M Tajuddin (SM)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
ORCID: 0000-0002-7919-8528

Andrej Teren (A)

LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Heart Centre Leipzig, Leipzig, Germany.

Joachim Thiery (J)

LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.

Chris H L Thio (CHL)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-2623-7172

Unnur Thorsteinsdottir (U)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.

Daniela Toniolo (D)

San Raffaele Research Institute, Milano, Italy.

Anke Tönjes (A)

Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.

Johanne Tremblay (J)

Montreal University Hospital Research Centre, Centre Hospitalier de lUniversité de Montréal, Montreal, Quebec, Canada.
Centre de Recherche du CHUM, Montreal, Quebec, Canada.

André G Uitterlinden (AG)

Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ORCID: 0000-0002-7276-3387

Simona Vaccargiu (S)

Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.

Pim van der Harst (P)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Durrer Centre for Cardiovascular Research, the Netherlands Heart Institute, Utrecht, the Netherlands.
ORCID: 0000-0002-2713-686X

Cornelia M van Duijn (CM)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.

Niek Verweij (N)

Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Genomics plc, Oxford, UK.
ORCID: 0000-0002-4303-7685

Uwe Völker (U)

DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-5689-3448

Peter Vollenweider (P)

Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Gerard Waeber (G)

Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.

Melanie Waldenberger (M)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany.
German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany.

John B Whitfield (JB)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0002-1103-0876

Sarah H Wild (SH)

Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-7824-2569

James F Wilson (JF)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-5751-9178

Qiong Yang (Q)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
ORCID: 0000-0002-3658-1375

Weihua Zhang (W)

Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
Department of Cardiology, Ealing Hospital, London, UK.

Alan B Zonderman (AB)

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.

Murielle Bochud (M)

Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.

James G Wilson (JG)

Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA.

Sarah A Pendergrass (SA)

Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.

Kevin Ho (K)

Kidney Health Research Institute, Geisinger, Danville, PA, USA.
Department of Nephrology, Geisinger, Danville, PA, USA.

Afshin Parsa (A)

Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Peter P Pramstaller (PP)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Carsten A Böger (CA)

Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Department of Nephrology and Rheumatology, Kliniken Südostbayern AG, Traunstein, Germany.

Harold Snieder (H)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-1949-2298

Adam S Butterworth (AS)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Yukinori Okada (Y)

Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Osaka, Japan.
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
ORCID: 0000-0002-0311-8472

Todd L Edwards (TL)

Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA.
Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0003-4318-6119

Kari Stefansson (K)

deCODE Genetics, Amgen Inc., Reykjavik, Iceland.
ORCID: 0000-0003-1676-864X

Katalin Susztak (K)

Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA.

Markus Scholz (M)

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
ORCID: 0000-0002-4059-1779

Iris M Heid (IM)

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

Adriana M Hung (AM)

Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA.
Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
ORCID: 0000-0002-3203-1608

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.

Cristian Pattaro (C)

Eurac Research, Institute for Biomedicine, Bolzano, Italy.

Owen M Woodward (OM)

Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0001-9514-2180

Veronique Vitart (V)

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-4991-3797

Anna Köttgen (A)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de.
Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de.
ORCID: 0000-0002-4671-3714

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Sous-famille G des transporteurs à cassette liant l'ATP › Membre-2 de la sous-famille G des transporteurs à cassette liant l'ATP › Target genes, variants, tissues and...
questionsmedicales.fr › Maladies cardiovasculaires › Target genes, variants, tissues and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Target genes, variants, tissues and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Target genes, variants, tissues and...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Marqueurs génétiques › Target genes, variants, tissues and...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Target genes, variants, tissues and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Target genes, variants, tissues and...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme de la purine et de la pyrimidine › Goutte › Target genes, variants, tissues and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs nucléaires hépatocytaires › Facteur nucléaire hépatocytaire HNF-1 › Facteur nucléaire hépatocytaire HNF-1 alpha › Target genes, variants, tissues and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs nucléaires hépatocytaires › Facteur nucléaire hépatocytaire HNF-4 › Target genes, variants, tissues and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Target genes, variants, tissues and...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Target genes, variants, tissues and...
questionsmedicales.fr › Système digestif › Foie › Target genes, variants, tissues and...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Target genes, variants, tissues and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Target genes, variants, tissues and...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Target genes, variants, tissues and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Target genes, variants, tissues and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Target genes, variants, tissues and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Acide urique › Target genes, variants, tissues and...