Haplotypes of
Aged
Aged, 80 and over
Alleles
Biomarkers
/ blood
Case-Control Studies
Complement Factor I
/ genetics
DNA Helicases
/ blood
DNA Repair Enzymes
/ blood
Female
Gene Expression
Gene Frequency
Genetic Predisposition to Disease
Haplotypes
High-Temperature Requirement A Serine Peptidase 1
/ blood
Humans
Macular Degeneration
/ blood
Male
Middle Aged
Odds Ratio
Poly-ADP-Ribose Binding Proteins
/ blood
Polymorphism, Single Nucleotide
Potassium Channels, Voltage-Gated
/ blood
Risk
Tissue Inhibitor of Metalloproteinase-3
/ blood
Vascular Endothelial Growth Factor A
/ blood
Journal
Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
03
2019
revised:
30
06
2019
accepted:
19
08
2019
entrez:
5
10
2019
pubmed:
5
10
2019
medline:
23
2
2020
Statut:
epublish
Résumé
To determine the impact of A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD, and 306 healthy controls. The genotyping of Our study showed that single-nucleotide polymorphisms rs3793784 and rs11200638 were associated with increased odds of early and exudative AMD, and the variant in Our study identified two markers, rs11200638 and rs3793784, as risk factors for early and exudative AMD, and one marker, rs56209061, as a protective factor for early and exudative AMD development. The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.
Sections du résumé
BACKGROUND
BACKGROUND
To determine the impact of
METHODS
METHODS
A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD, and 306 healthy controls. The genotyping of
RESULTS
RESULTS
Our study showed that single-nucleotide polymorphisms rs3793784 and rs11200638 were associated with increased odds of early and exudative AMD, and the variant in
CONCLUSIONS
CONCLUSIONS
Our study identified two markers, rs11200638 and rs3793784, as risk factors for early and exudative AMD, and one marker, rs56209061, as a protective factor for early and exudative AMD development. The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.
Identifiants
pubmed: 31583032
doi: 10.1155/2019/9602949
pmc: PMC6754896
doi:
Substances chimiques
Biomarkers
0
KCTD10 protein, human
0
Poly-ADP-Ribose Binding Proteins
0
Potassium Channels, Voltage-Gated
0
TIMP3 protein, human
0
Tissue Inhibitor of Metalloproteinase-3
0
VEGFA protein, human
0
Vascular Endothelial Growth Factor A
0
High-Temperature Requirement A Serine Peptidase 1
EC 3.4.21.-
HTRA1 protein, human
EC 3.4.21.-
CFI protein, human
EC 3.4.21.45
Complement Factor I
EC 3.4.21.45
DNA Helicases
EC 3.6.4.-
ERCC6 protein, human
EC 3.6.4.12
DNA Repair Enzymes
EC 6.5.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9602949Informations de copyright
Copyright © 2019 Rasa Liutkeviciene et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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