Digital ischemia in Behçet's disease: case-based review.
Anti-Inflammatory Agents
/ therapeutic use
Antirheumatic Agents
/ therapeutic use
Aspirin
/ therapeutic use
Azathioprine
/ therapeutic use
Behcet Syndrome
/ drug therapy
Colchicine
/ therapeutic use
Electromyography
Fingers
/ blood supply
Humans
Ischemia
/ drug therapy
Male
Middle Aged
Polyneuropathies
/ physiopathology
Prednisone
/ therapeutic use
Toes
/ blood supply
Tubulin Modulators
/ therapeutic use
Vasculitis
/ drug therapy
Behçet’s disease
Digital ischemia
Vasculitis
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
17
07
2019
accepted:
26
09
2019
pubmed:
11
10
2019
medline:
13
2
2021
entrez:
11
10
2019
Statut:
ppublish
Résumé
Behçet's disease is a rare chronic autoimmune disease affecting primarily Middle and East Asian populations between the ages of 20 and 40 years. Behçet's disease manifests with oral and genital mucocutaneous lesions, ocular disease, venous thrombosis, and central nervous system degradation. Treatment can be challenging and may require immunosuppressive agents and/or topical wound-care. While larger vascular involvement has been reported, digital ischemia due to small-vessel involvement has not been well described in the literature. Based on a systematic literature review, we were only able to find seven published cases of limb ischemia, none of which reported digital involvement. We present a unique case of Behçet's disease with severe digital ischemia and ulceration caused by small-vessel involvement. The patient was managed successfully with antiplatelet, immunosuppressants, and anti-inflammatories with complete resolution of the ischemic symptoms. By focusing on small-vessel involvement and digital ischemia, we provide insight into clinical presentation and treatment for this very rare vascular manifestation of Behçet's disease.
Identifiants
pubmed: 31598753
doi: 10.1007/s00296-019-04452-z
pii: 10.1007/s00296-019-04452-z
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antirheumatic Agents
0
Tubulin Modulators
0
Azathioprine
MRK240IY2L
Aspirin
R16CO5Y76E
Colchicine
SML2Y3J35T
Prednisone
VB0R961HZT
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-143Références
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