Ageing augments nicotinic and adenosine triphosphate-induced, but not muscarinic, cutaneous vasodilatation in women.
Adenosine Triphosphate
/ pharmacology
Adolescent
Adult
Aged
Aging
/ drug effects
Dose-Response Relationship, Drug
Female
Forearm
/ blood supply
Humans
Laser-Doppler Flowmetry
/ methods
Methacholine Chloride
/ pharmacology
Microcirculation
/ drug effects
Middle Aged
Muscarinic Agonists
/ pharmacology
Nicotine
/ pharmacology
Skin
/ blood supply
Vasodilation
/ drug effects
Young Adult
ageing
elderly
endothelium-dependent vasodilatation
gender
microcirculation
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
31
08
2019
accepted:
08
10
2019
pubmed:
12
10
2019
medline:
5
9
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
What is the central question of this study? Does ageing augment muscarinic, nicotinic and/or ATP-mediated cutaneous vasodilatation in women? What is the main finding and its importance? Ageing augments nicotinic and ATP-induced, but not muscarinic, cutaneous vasodilatation in women. This will stimulate future studies assessing the pathophysiological significance of the augmented microvascular responsiveness in older women compared to their young counterparts. We previously reported that ageing attenuates adenosine triphosphate (ATP)-induced, but not muscarinic and nicotinic, cutaneous vasodilatation in men, and that ageing may augment cutaneous vascular responses in women. In the present study, we evaluated the hypothesis that ageing augments muscarinic, nicotinic and/or ATP-mediated cutaneous vasodilatation in healthy women. In 11 young (23 ± 5 years) and 11 older (60 ± 8 years) women, cutaneous vascular conductance was evaluated at three forearm skin sites that were perfused with (1) methacholine (muscarinic receptor agonist, 5 doses: 0.0125, 0.25, 5, 100, 2000 mm), (2) nicotine (nicotinic receptor agonist, 5 doses: 1.2, 3.6, 11, 33, 100 mm), or (3) ATP (purinergic receptor agonist, 5 doses: 0.03, 0.3, 3, 30, 300 mm). Each agonist was administered for 25 min per dose. Methacholine-induced increases in cutaneous vascular conductance were not different between groups at all doses (all P > 0.05). However, a nicotine-induced elevation in cutaneous vascular conductance at the lowest concentration (1.2 mm) was greater in older vs. young women (43 ± 15 vs. 26 ± 10%max, P = 0.04). ATP-induced increases in cutaneous vascular conductance at moderate and high doses (3 and 30 mm) were also greater in older relative to young women (3 mm, 44 ± 11 vs. 28 ± 10%max, P = 0.02; 30 mm, 83 ± 14 vs. 64 ± 17%max, P = 0.05). Therefore, ageing augments nicotinic and ATP-induced, but not muscarinic, cutaneous vasodilatation in women.
Substances chimiques
Muscarinic Agonists
0
Methacholine Chloride
0W5ETF9M2K
Nicotine
6M3C89ZY6R
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1801-1807Subventions
Organisme : CIHR
ID : 399434
Pays : Canada
Informations de copyright
© 2019 The Authors. Experimental Physiology © 2019 The Physiological Society.
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