Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH.
Adrenocorticotropic Hormone
/ pharmacology
Animals
Cell Line
Cell Nucleus
/ metabolism
Female
Hormones
/ pharmacology
Mice
Phosphoproteins
/ genetics
Promoter Regions, Genetic
Protein Transport
/ drug effects
RNA, Heterogeneous Nuclear
/ genetics
Rats
Signal Transduction
/ drug effects
Transcription Factors
/ metabolism
Transcriptional Activation
/ drug effects
Adrenal cortex
CREB
CRTC
StAR
Steroidogenesis
Transcription
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
03
06
2019
revised:
06
09
2019
accepted:
04
10
2019
pubmed:
12
10
2019
medline:
21
10
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
Studies in vivo have suggested the involvement of CREB-regulated transcription coactivator (CRTC)2 on ACTH-induced transcription of the key steroidogenic protein, Steroidogenic Acute Regulatory (StAR). The present study uses two ACTH-responsive adrenocortical cell lines, to examine the role of CRTC on Star transcription. Here we show that ACTH-induced Star primary transcript, or heteronuclear RNA (hnRNA), parallels rapid increases in nuclear levels of the 3 isoforms of CRTC; CRTC1, CRTC2 and CRTC3. Furthermore, ACTH promotes recruitment of CRTC2 and CRTC3 by the Star promoter and siRNA knockdown of either CRTC3 or CRTC2 attenuates the increases in ACTH-induced Star hnRNA. Using pharmacological inhibitors of PKA, MAP kinase and calcineurin, we show that the effects of ACTH on Star transcription and CRTC nuclear translocation depend predominantly on the PKA pathway. The data provides evidence that CRTC2 and CRTC3, contribute to activation of Star transcription by ACTH, and that PKA/CRTC-dependent pathways are part of the multifactorial mechanisms regulating Star transcription.
Identifiants
pubmed: 31604124
pii: S0303-7207(19)30314-4
doi: 10.1016/j.mce.2019.110612
pmc: PMC6899503
pii:
doi:
Substances chimiques
Hormones
0
Phosphoproteins
0
RNA, Heterogeneous Nuclear
0
Transcription Factors
0
steroidogenic acute regulatory protein
0
Adrenocorticotropic Hormone
9002-60-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110612Subventions
Organisme : Medical Research Council
ID : MR/J008893/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010919/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Biochem Biophys Res Commun. 1996 Jun 5;223(1):12-8
pubmed: 8660356
Genes Dev. 1995 Jul 1;9(13):1608-21
pubmed: 7628695
J Clin Endocrinol Metab. 1997 Jan;82(1):234-8
pubmed: 8989265
J Biol Chem. 2001 Sep 14;276(37):34888-95
pubmed: 11410589
Endocrinology. 2019 Mar 1;160(3):587-604
pubmed: 30768667
J Biol Chem. 1997 Dec 19;272(51):32656-62
pubmed: 9405483
Proc Natl Acad Sci U S A. 1965 Jun;53(6):1443-50
pubmed: 4285998
Am J Physiol. 1984 Nov;247(5 Pt 2):R866-71
pubmed: 6496772
Mol Cell Biol. 2010 May;30(9):2155-69
pubmed: 20194623
Front Endocrinol (Lausanne). 2016 Feb 29;7:17
pubmed: 26973596
Cancer Res. 1966 Mar;26(3):529-35
pubmed: 5930699
Biochemistry. 1997 Jun 10;36(23):7249-55
pubmed: 9188726
J Neuroendocrinol. 2011 Aug;23(8):754-66
pubmed: 21679259
Am J Physiol. 1985 Jan;248(1 Pt 1):E89-94
pubmed: 2981481
Mol Endocrinol. 2013 Nov;27(11):1796-807
pubmed: 24065704
Cell. 2004 Oct 1;119(1):61-74
pubmed: 15454081
Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar;5(1):93-108
pubmed: 15777208
J Neurosci. 2015 Sep 2;35(35):12248-60
pubmed: 26338335
J Biol Chem. 1963 Aug;238:2754-9
pubmed: 14063299
Mol Cell Endocrinol. 2007 Feb;265-266:196-204
pubmed: 17210223
Endocr J. 2007 Aug;54(4):585-92
pubmed: 17634670
J Biol Chem. 1981 Nov 10;256(21):11365-71
pubmed: 6270152
EMBO J. 2013 May 29;32(11):1568-83
pubmed: 23665916
Mol Cell Endocrinol. 2015 Jun 15;408:80-9
pubmed: 25662274
J Biol Chem. 1972 May 25;247(10):3134-8
pubmed: 4337507
Endocrinology. 2008 Jul;149(7):3512-20
pubmed: 18372325
J Mol Endocrinol. 2002 Aug;29(1):163-74
pubmed: 12200237
Endocrinology. 2002 Jan;143(1):295-303
pubmed: 11751621
J Mol Endocrinol. 2003 Jun;30(3):381-97
pubmed: 12790807
Endocrinology. 1997 Nov;138(11):4893-901
pubmed: 9348220
Mol Endocrinol. 2002 Jan;16(1):184-99
pubmed: 11773448
Mol Cell Endocrinol. 2018 Feb 5;461:226-235
pubmed: 28942102
J Endocrinol. 2002 Mar;172(3):583-93
pubmed: 11874707
Endocr Res. 2000 Nov;26(4):873-7
pubmed: 11196465
EMBO J. 2010 Nov 3;29(21):3660-72
pubmed: 20859256
Mol Cell Endocrinol. 2013 May 22;371(1-2):62-70
pubmed: 23138111
Biochem Pharmacol. 1996 Feb 9;51(3):197-205
pubmed: 8573184
J Neuroendocrinol. 2011 Feb;23(2):136-42
pubmed: 21083631
Endocrinology. 2006 Apr;147(4):1805-18
pubmed: 16439455
Mol Cell Endocrinol. 2013 May 22;371(1-2):114-23
pubmed: 23178164
Braz J Med Biol Res. 1996 Mar;29(3):343-5
pubmed: 8736127
Endocrinology. 2012 Sep;153(9):4346-53
pubmed: 22822164
Endocrinology. 2011 Apr;152(4):1448-57
pubmed: 21303945
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3087-92
pubmed: 20133702
Genes Dev. 1996 Nov 1;10(21):2657-83
pubmed: 8946909
Mol Cell. 2003 Aug;12(2):413-23
pubmed: 14536081
Endocrinology. 2010 Mar;151(3):1109-18
pubmed: 20080871
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20865-70
pubmed: 23213254
J Clin Endocrinol Metab. 1995 Dec;80(12):3750-7
pubmed: 8530629
Mol Endocrinol. 2006 Jan;20(1):147-66
pubmed: 16109736
PLoS One. 2016 Jul 12;11(7):e0159181
pubmed: 27404111
Brain. 2013 Dec;136(Pt 12):3753-65
pubmed: 24271563
Mol Cell Endocrinol. 2011 Apr 10;336(1-2):53-62
pubmed: 21147196
Eur J Biochem. 2004 Nov;271(21):4307-19
pubmed: 15511237
Microsc Res Tech. 2003 Jun 15;61(3):268-74
pubmed: 12768542
Mol Cell Endocrinol. 2001 Feb 28;173(1-2):183-92
pubmed: 11223189
Endocrinology. 2011 Jan;152(1):313-25
pubmed: 21047949
Endocrinology. 1986 Sep;119(3):1010-9
pubmed: 3015562
J Biol Chem. 2001 Dec 7;276(49):46583-96
pubmed: 11579102
J Biol Chem. 2011 Sep 23;286(38):32976-85
pubmed: 21808064
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84
pubmed: 16980408
Curr Biol. 2004 Dec 14;14(23):2156-61
pubmed: 15589160
Endocrinology. 2001 Oct;142(10):4282-7
pubmed: 11564685
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12147-52
pubmed: 14506290
J Neuroendocrinol. 2011 Mar;23(3):216-23
pubmed: 21121974
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6466-E6474
pubmed: 28716938
J Neuroendocrinol. 1996 Sep;8(9):659-72
pubmed: 8877815
Proc Natl Acad Sci U S A. 1985 Dec;82(23):7860-4
pubmed: 2999780
Mol Cell Endocrinol. 2004 Dec 30;228(1-2):23-38
pubmed: 15541570
Endocr Res. 2000 Nov;26(4):885-98
pubmed: 11196467
Endocrinology. 1998 Dec;139(12):4820-31
pubmed: 9832418
Mol Endocrinol. 2001 Aug;15(8):1264-76
pubmed: 11463852
Biochem Biophys Res Commun. 1995 Jul 26;212(3):912-8
pubmed: 7626130
J Clin Endocrinol Metab. 1971 Jul;33(1):14-22
pubmed: 4326799
J Mol Biol. 2018 Jun 22;430(13):1926-1939
pubmed: 29733854
J Mol Endocrinol. 2014 Aug;53(1):1-16
pubmed: 24780837
J Natl Cancer Inst. 1960 Jan;24:97-107
pubmed: 13801497
Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E413-25
pubmed: 20551288