Trend of antidepressants before, during, and after pregnancy across two decades-A population-based study.
Adult
Antidepressive Agents
/ therapeutic use
Antidepressive Agents, Tricyclic
/ therapeutic use
Denmark
Depressive Disorder
/ drug therapy
Duration of Therapy
Female
Humans
Pregnancy
Pregnancy Complications
/ drug therapy
Selective Serotonin Reuptake Inhibitors
/ therapeutic use
Serotonin and Noradrenaline Reuptake Inhibitors
/ therapeutic use
Young Adult
antidepressants
depression
epidemiology
pregnancy
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
23
08
2019
accepted:
14
09
2019
pubmed:
16
10
2019
medline:
2
7
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
Factors that influence antidepressant (AD) prescription and use during pregnancy are multiple including, in particular, the balance between the potential risk of untreated depression and the potential risk of AD treatment. Surveillance of temporal trends of AD use might identify areas requiring further research. We studied the use of ADs before, during, and after pregnancy using national data across two decades in Denmark. We included 1,232,233 pregnancies leading to live birth in Denmark between 1 January 1997 and 31 December 2016. Information on redemption of AD prescriptions was obtained from the Danish National Prescription Register. We identified 29,504 (2.4%) pregnancies having at least one AD prescription (96,232 AD prescriptions) during pregnancy. The majority redeemed more than one prescription (69.7%) often for a single kind of AD (83.5%), and in 94% of the AD-exposed pregnancies, the estimated duration of treatment was 1 month or longer. Prescription of ADs during pregnancy increased steadily from 0.4% in 1997 to 4.6% in 2011, but decreased thereafter to 3.1% in 2016. The proportion of pregnancies with ADs in 2011 was 6.05-fold higher than that in 1997. The temporal trends in AD prescription in the years before and after pregnancy were similar to the trend during pregnancy. The decreasing use of ADs during pregnancy after 2011 was mainly driven by a decrease in the use of selective serotonin reuptake inhibitors (SSRIs), especially citalopram, the main type of SSRIs used in Denmark. Prescription of ADs during pregnancy in Denmark increased steadily from 1997 to 2011 but decreased sharply thereafter. More research is needed to show whether the same trend exists in other populations, like women of reproductive age, men of reproductive age, and old people, and other countries. We also need to find explanation for the decreasing trend in recent years and potential risk for untreated depression.
Identifiants
pubmed: 31613060
doi: 10.1002/brb3.1441
pmc: PMC6851806
doi:
Substances chimiques
Antidepressive Agents
0
Antidepressive Agents, Tricyclic
0
Serotonin Uptake Inhibitors
0
Serotonin and Noradrenaline Reuptake Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01441Subventions
Organisme : NIMH NIH HHS
ID : R01 MH104468
Pays : United States
Informations de copyright
© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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