Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Interactions with Synaptic Vesicle 2 Proteins and the GABA
Animals
Anticonvulsants
/ chemistry
COS Cells
Chlorocebus aethiops
GABA Agonists
/ chemistry
HEK293 Cells
Humans
Imidazoles
/ chemistry
Kinetics
Male
Membrane Glycoproteins
/ metabolism
Mice
Mice, Inbred C57BL
Nerve Tissue Proteins
/ metabolism
Protein Binding
Pyrrolidinones
/ chemistry
Rats
Rats, Sprague-Dawley
Receptors, GABA-A
/ metabolism
Thiadiazoles
/ chemistry
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
08
07
2019
accepted:
10
10
2019
pubmed:
18
10
2019
medline:
14
7
2020
entrez:
18
10
2019
Statut:
ppublish
Résumé
Padsevonil is an antiepileptic drug (AED) candidate synthesized in a medicinal chemistry program initiated to rationally design compounds with high affinity for synaptic vesicle 2 (SV2) proteins and low-to-moderate affinity for the benzodiazepine binding site on GABA
Identifiants
pubmed: 31619465
pii: jpet.119.261149
doi: 10.1124/jpet.119.261149
doi:
Substances chimiques
Anticonvulsants
0
GABA Agonists
0
Imidazoles
0
Membrane Glycoproteins
0
Nerve Tissue Proteins
0
Pyrrolidinones
0
Receptors, GABA-A
0
Thiadiazoles
0
padsevonil
0R1HN52K0N
SV2A protein, human
148845-93-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-10Informations de copyright
Copyright © 2019 The Author(s).