Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.

Animals Bacterial Proteins / genetics Cell Adhesion Molecules / genetics Cell Differentiation Cells, Cultured Colitis / chemically induced Colon / immunology Dendritic Cells / immunology Humans Inflammatory Bowel Diseases / immunology Lectins, C-Type / genetics Listeria / physiology Listeriosis / immunology Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout Propionibacterium / metabolism Protein Binding Receptors, Cell Surface / genetics Symbiosis T-Lymphocytes / immunology

Journal

Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742

Informations de publication

Date de publication:
01 2020
Historique:
received: 08 07 2019
accepted: 23 09 2019
revised: 30 08 2019
pubmed: 18 10 2019
medline: 8 1 2021
entrez: 18 10 2019
Statut: ppublish

Résumé

Microbial interaction with the host through sensing receptors, including SIGNR1, sustains intestinal homeostasis against pathogenic inflammation. The newly discovered commensal Propionibacterium strain, P. UF1, regulates the intestinal immunity against pathogen challenge. However, the molecular events driving intestinal phagocytic cell response, including colonic dendritic cells (DCs), by this bacterium are still elusive. Here, we demonstrate that the glycosylation of bacterial large surface layer protein A (LspA) by protein O-mannosyltransferase 1 (Pmt1) regulates the interaction with SIGNR1, resulting in the control of DC transcriptomic and metabolomic machineries. Programmed DCs promote protective T cell response to intestinal Listeria infection and resist chemically induced colitis in mice. Thus, our findings may highlight a novel molecular mechanism by which commensal surface glycosylation interacting with SIGNR1 directs the intestinal homeostasis to potentially protect the host against proinflammatory signals inducing colonic tissue damage.

Identifiants

DOI: 10.1038/s41385-019-0210-0 PMID: 31619761 PMC: PMC6917853
pubmed: 31619761
doi: 10.1038/s41385-019-0210-0
pii: S1933-0219(22)00239-2
pmc: PMC6917853
mid: NIHMS1540822
doi:

Substances chimiques

Bacterial Proteins 0
Cell Adhesion Molecules 0
DC-specific ICAM-3 grabbing nonintegrin 0
Lectins, C-Type 0
Receptors, Cell Surface 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

34-46

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK109560
Pays : United States
Organisme : NIH HHS
ID : S10 OD018530
Pays : United States

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Auteurs

Yong Ge (Y)

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, 32611, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, 32611, USA.

Minghao Gong (M)

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, 32611, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, 32611, USA.

Mojgan Zadeh (M)

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, 32611, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, 32611, USA.

Jing Li (J)

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, 32611, USA.

Jeffrey R Abbott (JR)

Department of Comparative, Diagnostic and Population Medicine, University of Florida, Gainesville, FL, 32611, USA.

Wei Li (W)

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32611, USA.

Laurence Morel (L)

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32611, USA.

Roberto Sonon (R)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.

Nitin T Supekar (NT)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.

Parastoo Azadi (P)

Complex Carbohydrate Research Center, University of Georgia, Athens, GA, 30602, USA.

Yating Wang (Y)

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Dean P Jones (DP)

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Shuzhao Li (S)

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Mansour Mohamadzadeh (M)

Department of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, 32611, USA. m.zadeh@ufl.edu.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL, 32611, USA. m.zadeh@ufl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Regulating colonic dendritic cells by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Regulating colonic dendritic cells by...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Regulating colonic dendritic cells by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Regulating colonic dendritic cells by...
questionsmedicales.fr › Cellules › Cellules cultivées › Regulating colonic dendritic cells by...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Regulating colonic dendritic cells by...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › Regulating colonic dendritic cells by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Regulating colonic dendritic cells by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Regulating colonic dendritic cells by...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Regulating colonic dendritic cells by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Lectines de type C › Regulating colonic dendritic cells by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Listeria › Regulating colonic dendritic cells by...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Listeria › Regulating colonic dendritic cells by...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Regulating colonic dendritic cells by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Regulating colonic dendritic cells by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Regulating colonic dendritic cells by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Regulating colonic dendritic cells by...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Propionibacteriaceae › Propionibacterium › Regulating colonic dendritic cells by...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Regulating colonic dendritic cells by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Regulating colonic dendritic cells by...
questionsmedicales.fr › Phénomènes biologiques › Symbiose › Regulating colonic dendritic cells by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Regulating colonic dendritic cells by...