Effects of Peptide YY on the Hypothalamic-Pituitary-Gonadal Axis in Healthy Men.
Adolescent
Adult
Biomarkers
/ blood
Cross-Over Studies
Follicle Stimulating Hormone
/ blood
Follow-Up Studies
Healthy Volunteers
Humans
Hypothalamo-Hypophyseal System
/ drug effects
Luteinizing Hormone
/ blood
Male
Peptide YY
/ pharmacology
Prognosis
Single-Blind Method
Testosterone
/ blood
Young Adult
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 03 2020
01 03 2020
Historique:
received:
08
07
2019
accepted:
02
10
2019
pubmed:
20
10
2019
medline:
11
11
2020
entrez:
20
10
2019
Statut:
ppublish
Résumé
Central and peripheral administration of peptide YY (PYY) has potent anorectic effects, and PYY analogs are under development as antiobesity treatments. Recent animal data suggest PYY may also influence the reproductive axis; however the effects of PYY on the human reproductive system are unknown. To investigate the effects of PYY administration on the reproductive axis in healthy young men. Single-blind, randomized, placebo-controlled crossover study. Clinical Research Facility, Imperial College Healthcare NHS Trust. Eighteen healthy eugonadal men (mean age 24.1 ± 0.9 years, mean body mass index 22.2 ± 0.4 kg/m2). Eight-hour intravenous infusion of 0.4 pmol/kg/min PYY3-36 or rate-matched vehicle infusion. Number of luteinizing hormone (LH) pulses, LH, follicle stimulating hormone (FSH), and testosterone levels. The number of LH pulses (mean number of LH pulses/8 hours: PYY 4.4 ± 0.3 vs vehicle 4.4 ± 0.4, P > .99), LH area under the curve (AUC) (PYY 1503 ± 79 IU.min/L vs vehicle 1574 ± 86 IU.min/L, P = .36), FSH AUC (PYY 1158 ± 513 IU.min/L vs vehicle 1199 ± 476 IU.min/L, P = .49) and testosterone AUC (PYY 10 485 ± 684 IU.min/L vs vehicle 11 133 ± 803 IU.min/L, P = .24) were similar during PYY and vehicle infusions. Acute intravenous infusion of 0.4 pmol/kg/min PYY does not affect the reproductive axis in healthy men.
Identifiants
pubmed: 31628465
pii: 5599746
doi: 10.1210/clinem/dgz103
pmc: PMC7093052
pii:
doi:
Substances chimiques
Biomarkers
0
Peptide YY
106388-42-5
Testosterone
3XMK78S47O
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N020472/1
Pays : United Kingdom
Organisme : Department of Health
ID : CS-2018-18-ST2-002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R000484/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T006242/1
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2014-05-001
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M004171/1
Pays : United Kingdom
Informations de copyright
© Endocrine Society 2019.
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