Inhibition of NAMPT markedly enhances plasma-activated medium-induced cell death in human breast cancer MDA-MB-231 cells.
Acrylamides
/ pharmacology
Breast Neoplasms
/ pathology
Cell Death
/ drug effects
Cell Line, Tumor
Culture Media
/ pharmacology
Drug Synergism
Energy Metabolism
/ drug effects
Enzyme Inhibitors
/ pharmacology
Humans
Kinetics
Nicotinamide Phosphoribosyltransferase
/ antagonists & inhibitors
Oxidative Stress
/ drug effects
Piperidines
/ pharmacology
Plasma Gases
/ pharmacology
FK866
NAD(+) metabolism
Nicotinamide phosphoribosyltransferase
Non-thermal atmospheric pressure plasma
Reactive oxygen species
Journal
Archives of biochemistry and biophysics
ISSN: 1096-0384
Titre abrégé: Arch Biochem Biophys
Pays: United States
ID NLM: 0372430
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
09
09
2019
revised:
04
10
2019
accepted:
15
10
2019
pubmed:
20
10
2019
medline:
31
3
2020
entrez:
20
10
2019
Statut:
ppublish
Résumé
Plasma-activated medium (PAM), which is prepared by non-thermal atmospheric pressure plasma (NTP) irradiation of cell-free medium, has been shown to exhibit tumor-specific cytotoxicity. Since PAM contains reactive oxygen species (ROS) and reactive nitrogen species (RNS), its anticancer effects are considered to be responsible for oxidative stress induced by these reactive molecules. We previously reported that PAM-induced cell death is closely related to energy failure associated with a decrease in intracellular nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 31628926
pii: S0003-9861(19)30787-8
doi: 10.1016/j.abb.2019.108155
pii:
doi:
Substances chimiques
Acrylamides
0
Culture Media
0
Enzyme Inhibitors
0
N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
0
Piperidines
0
Plasma Gases
0
Nicotinamide Phosphoribosyltransferase
EC 2.4.2.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108155Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.