Minocycline induces the expression of intra-accumbal glutamate transporter-1 in the morphine-dependent rats.
Glutamate transporter 1
Immunohistochemistry
Minocycline
Morphine dependency
Nucleus accumbens
Rat
Journal
Asian journal of psychiatry
ISSN: 1876-2026
Titre abrégé: Asian J Psychiatr
Pays: Netherlands
ID NLM: 101517820
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
27
07
2019
revised:
06
10
2019
accepted:
07
10
2019
pubmed:
21
10
2019
medline:
11
4
2020
entrez:
21
10
2019
Statut:
ppublish
Résumé
Glial glutamate transporters (GLT-1) is responsible for glutamate homeostasis. GLT-1 expression and glutamate uptake can be affected by addictive drugs and can be used as a target in addiction pharmacotherapy. It has been shown that minocycline, an antibiotic with anti-inflammatory, and neuroprotective properties, can upregulate the expression of GLT-1. In the present study, in morphine-dependent rats, the effect of minocycline on expression of GLT-1 in nucleus accumbens was investigated by immunohistochemistry. The expression of GLT-1 significantly increased in minocycline treated animals. In line with other studies, our findings showed that restoring GLT-1 expression with minocycline might be considered as a potential target for correcting pre-clinical and clinical manifestations of drug addiction.
Identifiants
pubmed: 31630007
pii: S1876-2018(19)30559-3
doi: 10.1016/j.ajp.2019.10.007
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Excitatory Amino Acid Transporter 2
0
Slc1a2 protein, rat
0
Morphine
76I7G6D29C
Minocycline
FYY3R43WGO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-73Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.