Psychiatric comorbidities in alcohol use disorder.
Journal
The lancet. Psychiatry
ISSN: 2215-0374
Titre abrégé: Lancet Psychiatry
Pays: England
ID NLM: 101638123
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
17
01
2019
revised:
13
05
2019
accepted:
30
05
2019
pubmed:
22
10
2019
medline:
28
1
2020
entrez:
22
10
2019
Statut:
ppublish
Résumé
Alcohol use disorder is a major contributor to the morbidity and mortality burden worldwide. It often coexists with other psychiatric disorders; however, the nature of this comorbidity is still a matter of debate. In this Series paper, we examine the main psychiatric disorders associated with alcohol use disorder, including the prevalence of co-occurring disorders, the temporal nature of the relationship, and mechanisms that might explain comorbidity across the lifespan. Overall, this disorder co-occurs with a wide range of other psychiatric disorders, especially those disorders involving substance use and violent or aggressive behaviour. The causal pathways between alcohol use disorder and other psychiatric disorders are heterogeneous. Hypotheses explaining these relationships include reciprocal direct causal associations, shared genetic and environmental causes, and shared psychopathological characteristics of broader diagnostic entities (eg, externalising disorders). Efforts to untangle the associations between alcohol use disorder and other disorders across the lifespan remain a crucial avenue of research.
Identifiants
pubmed: 31630984
pii: S2215-0366(19)30222-6
doi: 10.1016/S2215-0366(19)30222-6
pmc: PMC7006178
mid: NIHMS1068684
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1068-1080Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA025309
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA021511
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA041154
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA018652
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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