Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.

Anti-Asthmatic Agents / chemistry Binding Sites Chromones / chemistry Crystallography, X-Ray Humans Indoles Leukotriene Antagonists / chemistry Ligands Molecular Docking Simulation Phenylcarbamates Protein Structure, Tertiary Receptors, Leukotriene / chemistry Recombinant Proteins / biosynthesis Sodium / chemistry Sulfonamides Tosyl Compounds / chemistry

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
10 2019
Historique:
received: 08 03 2019
accepted: 18 09 2019
entrez: 22 10 2019
pubmed: 22 10 2019
medline: 20 5 2020
Statut: epublish

Résumé

The G protein-coupled cysteinyl leukotriene receptor CysLT

Identifiants

DOI: 10.1126/sciadv.aax2518 PMID: 31633023 PMC: PMC6785256
pubmed: 31633023
doi: 10.1126/sciadv.aax2518
pii: aax2518
pmc: PMC6785256
doi:

Substances chimiques

Anti-Asthmatic Agents 0
Chromones 0
Indoles 0
Leukotriene Antagonists 0
Ligands 0
Phenylcarbamates 0
Receptors, Leukotriene 0
Recombinant Proteins 0
Sulfonamides 0
Tosyl Compounds 0
Sodium 9NEZ333N27
leukotriene D4 receptor LRF7RW46ID
pranlukast TB8Z891092
zafirlukast XZ629S5L50

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaax2518

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM124152
Pays : United States

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Aleksandra Luginina (A)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
ORCID: 0000-0003-2697-456X

Anastasiia Gusach (A)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
ORCID: 0000-0002-2594-8573

Egor Marin (E)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
ORCID: 0000-0003-2369-1732

Alexey Mishin (A)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
ORCID: 0000-0003-3759-380X

Rebecca Brouillette (R)

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.
ORCID: 0000-0002-5466-9653

Petr Popov (P)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.

Anna Shiriaeva (A)

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.

Élie Besserer-Offroy (É)

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.
ORCID: 0000-0002-7473-7043

Jean-Michel Longpré (JM)

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.
ORCID: 0000-0003-3985-2318

Elizaveta Lyapina (E)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
ORCID: 0000-0003-0719-8497

Andrii Ishchenko (A)

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.

Nilkanth Patel (N)

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
ORCID: 0000-0002-9856-3041

Vitaly Polovinkin (V)

Institute of Complex Systems, ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.
Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble 38000, France.
ELI Beamlines, Institute of Physics, Czech Academy of Sciences, 18221 Prague, Czech Republic.
ORCID: 0000-0002-3630-5565

Nadezhda Safronova (N)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
ORCID: 0000-0002-7770-0174

Andrey Bogorodskiy (A)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.

Evelina Edelweiss (E)

Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble 38000, France.

Hao Hu (H)

Department of Physics, Arizona State University, Tempe, AZ 85287, USA.
Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
ORCID: 0000-0003-3472-0404

Uwe Weierstall (U)

Department of Physics, Arizona State University, Tempe, AZ 85287, USA.
Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
ORCID: 0000-0002-3594-930X

Wei Liu (W)

Biodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.

Alexander Batyuk (A)

Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
ORCID: 0000-0002-9393-2880

Valentin Gordeliy (V)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
Institute of Complex Systems, ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.
Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble 38000, France.
Juelich Center for Structural Biology, Research Center Juelich, Juelich, Germany.
Institute of Crystallography, RWTH Aachen University, Aachen, Germany.

Gye Won Han (GW)

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
ORCID: 0000-0003-4107-835X

Philippe Sarret (P)

Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.
ORCID: 0000-0002-7627-701X

Vsevolod Katritch (V)

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
ORCID: 0000-0003-3883-4505

Valentin Borshchevskiy (V)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
Institute of Complex Systems, ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.
Juelich Center for Structural Biology, Research Center Juelich, Juelich, Germany.
ORCID: 0000-0003-4398-9712

Vadim Cherezov (V)

Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
ORCID: 0000-0002-5265-3914

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Antiasthmatiques › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Antihormones › Antagonistes des leucotriènes › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Carbamates › Phényl-carbamates › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteurs aux leucotriènes › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Structure-based mechanism of cysteinyl...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Composés tosyliques › Structure-based mechanism of cysteinyl...