High-Level Carbapenem Resistance in OXA-232-Producing Raoultella ornithinolytica Triggered by Ertapenem Therapy.
Bacterial Proteins
/ biosynthesis
Carbapenem-Resistant Enterobacteriaceae
/ drug effects
Carbapenems
/ pharmacology
Enterobacteriaceae
/ drug effects
Enterobacteriaceae Infections
/ drug therapy
Ertapenem
/ pharmacology
Genes, Bacterial
Humans
Male
Mutation
Porins
/ genetics
Whole Genome Sequencing
beta-Lactam Resistance
/ genetics
beta-Lactamases
/ biosynthesis
carbapenem resistance
carbapenemase
oxacillinase
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
20 12 2019
20 12 2019
Historique:
received:
01
07
2019
accepted:
14
10
2019
pubmed:
23
10
2019
medline:
1
9
2020
entrez:
23
10
2019
Statut:
epublish
Résumé
OXA-232 is an OXA-48-group class D β-lactamase that hydrolyzes expanded-spectrum cephalosporins and carbapenems at low levels. Clinical strains producing OXA-232 are sometimes susceptible to carbapenems, making it difficult to identify them in the clinical microbiology laboratory. We describe the development of carbapenem resistance in sequential clinical isolates of
Identifiants
pubmed: 31636064
pii: AAC.01335-19
doi: 10.1128/AAC.01335-19
pmc: PMC7187609
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Carbapenems
0
OmpC protein
0
OmpF protein
0
Porins
0
beta-Lactamases
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
Ertapenem
G32F6EID2H
Types de publication
Case Reports
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : K08 AI114883
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104895
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI124302
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI144636
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI135522
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM110444
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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