Changes in growth hormone secretion and leptin receptor mRNA expression under the influence of leptin and adrenocorticotropin in pituitary cells of early weaned ewe lambs.
Journal
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
ISSN: 1899-1505
Titre abrégé: J Physiol Pharmacol
Pays: Poland
ID NLM: 9114501
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
24
05
2019
accepted:
28
08
2019
entrez:
24
10
2019
pubmed:
24
10
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
Early weaning of ewe lambs strongly stimulates the hypothalamic-pituitary-adrenal axis and is associated with suppressed growth rate despite the increased food intake. At the same time, plasma leptin concentration increases only slightly or undetectably. To better understand this atypical interdependence among somatic stress, leptin, and lamb growth rate, we analyzed impact of leptin and/or adrenocorticotropic hormone (ACTH) on growth hormone (GH) secretion as well as the effect of ACTH on mRNA expression of two splice variants of leptin receptor (LEPRa, LEPRb) in pituitary cells isolated from early weaned ewe lambs. The GH secretion under the influence of leptin and/or ACTH depended on the timing of exposure and hormone concentration. After 6 - 30 h, GH secretion increased under 10
Identifiants
pubmed: 31642814
doi: 10.26402/jpp.2019.4.03
doi:
Substances chimiques
Leptin
0
RNA, Messenger
0
Receptors, Leptin
0
Adrenocorticotropic Hormone
9002-60-2
Growth Hormone
9002-72-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM