Membrane property changes in most distal motor axons in chronic inflammatory demyelinating polyneuropathy.
blood-nerve barrier
chronic inflammatory demyelinating polyneuropathy
distal latency
multiple excitability measurements
nerve terminal
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
04
03
2019
revised:
16
10
2019
accepted:
18
10
2019
pubmed:
28
10
2019
medline:
14
4
2020
entrez:
26
10
2019
Statut:
ppublish
Résumé
Distal nerve terminals, where the blood-nerve barrier is anatomically deficient, are preferentially affected in immune-mediated neuropathies. Excitability alterations near the motor nerve terminals may be more prominent than the nerve trunk in typical chronic inflammatory demyelinating polyneuropathy (CIDP). In 20 patients with typical CIDP, motor nerve excitability testing was performed at the motor point and wrist of the ulnar nerve, and results were compared with those in 20 healthy persons. Chronic inflammatory demyelinating polyneuropathy patients showed greater threshold changes in hyperpolarizing threshold electrotonus at the motor point (P < .05) but not at the wrist. Strength-duration time constant did not show significant differences between CIDP and controls at both sites. Axonal property changes in CIDP are more prominent in distal portions of axons compared with the nerve trunk, presumably due to salient demyelination near the distal nerve terminals. Motor point excitability measurements could elucidate underlying pathophysiology in immune-mediated neuropathies.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
238-242Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
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