A novel technique of antimicrobial photodynamic therapy - aPDT using 1,9-dimethyl-methylene blue zinc chloride double salt-DMMB and polarized light on Staphylococcus aureus.

Anti-Infective Agents / chemistry Chlorides / chemistry Light Methylene Blue / analogs & derivatives Photochemotherapy Photosensitizing Agents / chemistry Staphylococcus aureus / drug effects Zinc Compounds / chemistry
Gram-positive Phenothiazine Photoinactivation Staphylococcus spp

Journal

Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Titre abrégé: J Photochem Photobiol B
Pays: Switzerland
ID NLM: 8804966

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 22 05 2019
revised: 17 09 2019
accepted: 06 10 2019
pubmed: 28 10 2019
medline: 30 11 2019
entrez: 27 10 2019
Statut: ppublish

Résumé

Antimicrobial Photodynamic Therapy (aPDT) is an alternative to conventional treatments of local infections such as the use of antibiotics, which may lead to the development of resistance. aPDT besides requiring the use of a photosensitiser also needs a light source do be carried out. In the search for efficient and low-cost procedure the use of multispectral polarized light (λ400-2000 nm) emerges as a possibility for the execution of aPDT. The use of a highly effective photosensitizer is also of great importance. 1,9-Dimethyl-Methylene Blue Zinc Chloride Double Salt - DMMB is a potent phenothiazine derivative that presents high photodynamic action due to its high lipophilicity as well as a greater quantum yield of Singlet oxygen and phototoxicity when compared to other Photosensitizers. The aim of this study was to assess, In Vitro, the efficacy of aPDT on Staphylococcus aureus (ATCC 25923) using different concentrations of DMMB associated to a Polarized light source (Bioptron®, 40 mW, ᴓ = 15.8 cm

Identifiants

DOI: 10.1016/j.jphotobiol.2019.111646 PMID: 31655457
pubmed: 31655457
pii: S1011-1344(19)30649-9
doi: 10.1016/j.jphotobiol.2019.111646
pii:
doi:

Substances chimiques

Anti-Infective Agents 0
Chlorides 0
Photosensitizing Agents 0
Zinc Compounds 0
dimethylmethylene blue 0
zinc chloride 86Q357L16B
Methylene Blue T42P99266K

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111646

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Darcy de A Santos (DA)

Center of Health Science, Federal University of the Reconcavo Bahiano, Carlos Amaral Ave, 1015 - Cajueiro, Santo Antônio de Jesus, BA CEP: 44.574-490, Brazil; Center of Biophotonics, Federal University of Bahia, 62, Araujo Pinho Ave, Canela, Salvador, BA 40110-150, Brazil.

Pedro Jorge L Crugeira (PJL)

Center of Biophotonics, Federal University of Bahia, 62, Araujo Pinho Ave, Canela, Salvador, BA 40110-150, Brazil; Laboratory of Biotechnology and Ecology of Micro-organisms, Institute of Health Science, Federal University of Bahia, Reitor Miguel Calmon Ave, S/N, Salvador, BA CEP:40110-100, Brazil.

Iago P F Nunes (IPF)

Center of Biophotonics, Federal University of Bahia, 62, Araujo Pinho Ave, Canela, Salvador, BA 40110-150, Brazil.

Paulo Fernando de Almeida (PF)

Center of Biophotonics, Federal University of Bahia, 62, Araujo Pinho Ave, Canela, Salvador, BA 40110-150, Brazil; Laboratory of Biotechnology and Ecology of Micro-organisms, Institute of Health Science, Federal University of Bahia, Reitor Miguel Calmon Ave, S/N, Salvador, BA CEP:40110-100, Brazil. Electronic address: pfa@ufba.br.

Antônio Luiz B Pinheiro (ALB)

Center of Biophotonics, Federal University of Bahia, 62, Araujo Pinho Ave, Canela, Salvador, BA 40110-150, Brazil; Laboratory of Biotechnology and Ecology of Micro-organisms, Institute of Health Science, Federal University of Bahia, Reitor Miguel Calmon Ave, S/N, Salvador, BA CEP:40110-100, Brazil; National Institute Basic Optics and Applied to Life Science, 400, Trabalhador São-Carlense Ave, Parque Arnold Schimidt, São Carlos, SP CEP:13566-590, Brazil; Brasil University Scientific and Techological Institute, 235, Carolina Fonseca St, Itaquera, São Paulo, SP CEP:08230-030, Brazil. Electronic address: albp@ufba.br.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › A novel technique of antimicrobial...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › A novel technique of antimicrobial...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › A novel technique of antimicrobial...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénothiazines › Bleu de méthylène › A novel technique of antimicrobial...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › A novel technique of antimicrobial...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › A novel technique of antimicrobial...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › A novel technique of antimicrobial...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du zinc › A novel technique of antimicrobial...