Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review.
Brain
/ abnormalities
Female
Herpes Simplex
/ complications
Herpesvirus 1, Human
Herpesvirus 2, Human
Humans
Infant, Newborn
Keratitis, Herpetic
/ diagnosis
Microphthalmos
/ diagnostic imaging
Nervous System Malformations
/ diagnostic imaging
Pregnancy
Pregnancy Complications, Infectious
Ultrasonography, Prenatal
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
22
05
2019
revised:
30
09
2019
accepted:
06
10
2019
pubmed:
31
10
2019
medline:
25
3
2021
entrez:
31
10
2019
Statut:
ppublish
Résumé
Herpes simplex virus (HSV) infection during pregnancy can cause severe neonatal infections. It is also a rare cause of congenital infections. We aimed to describe fetal and neonatal abnormalities of congenital HSV infection in order to define the features that are accessible to prenatal diagnosis during ultrasound screening and/or during a work-up for congenital malformations. We analysed all cases of congenital HSV infection (CHI) described before and/or after birth and identified in Pubed and classified the findings as accessible or not to prenatal diagnosis. Thirty-six cases of congenital herpes infection were reported, of which 15 were described prenatally and 21 postnatally. The most frequently reported malformations accessible to prenatal diagnosis were cerebral anomalies. The most common abnormalities described after birth were skin lesions and keratitis, which are not considered amenable to prenatal ultrasound detection. CHI can due to either HSV1 or HSV2 infection, whether primary or non-primary infection, with or without the presence of maternal symptoms. Prenatal ultrasound abnormalities due to CHI are rare, varied and non-specific. There is no clear role for fetal ultrasound in the routine management of women with primary or non-primary HSV infection in pregnancy. However, in fetuses with ultrasound abnormalities suggestive of congenital infection, HSV should still be considered as a differential diagnosis after the more common in utero infections, such as cytomegalovirus, are excluded.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
408-414Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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