Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation of 1,4-Diazepan-5-ones.

Alkylation Azepines / chemical synthesis Catalysis Palladium / chemistry Sleep Aids, Pharmaceutical / chemical synthesis Triazoles / chemical synthesis

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
15 11 2019
Historique:
pubmed: 2 11 2019
medline: 4 9 2020
entrez: 1 11 2019
Statut: ppublish

Résumé

We report the palladium-catalyzed asymmetric allylic alkylation of 1,4-diazepan-5-ones. This reaction proceeds smoothly to give

Identifiants

DOI: 10.1021/acs.orglett.9b03530 PMID: 31668074 PMC: PMC8579948
pubmed: 31668074
doi: 10.1021/acs.orglett.9b03530
pmc: PMC8579948
mid: NIHMS1745701
doi:

Substances chimiques

Azepines 0
Sleep Aids, Pharmaceutical 0
Triazoles 0
suvorexant 081L192FO9
Palladium 5TWQ1V240M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9158-9161

Subventions

Organisme : NIGMS NIH HHS
ID : F30 GM120836
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM080269
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR027690
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008042
Pays : United States

Références

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pubmed: 31360407
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pubmed: 30707024
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pubmed: 22725839

Auteurs

Zachary P Sercel (ZP)

Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

Alexander W Sun (AW)

Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

Brian M Stoltz (BM)

Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.
ORCID: 0000-0001-9837-1528

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Classifications MeSH

questionsmedicales.fr › Métabolisme › Alkylation › Palladium-Catalyzed Decarboxylative Asymmetric...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azépines › Palladium-Catalyzed Decarboxylative Asymmetric...
questionsmedicales.fr › Phénomènes chimiques › Catalyse › Palladium-Catalyzed Decarboxylative Asymmetric...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Palladium › Palladium-Catalyzed Decarboxylative Asymmetric...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Hypnotiques et sédatifs › Produits pharmaceutiques favorisant le sommeil › Palladium-Catalyzed Decarboxylative Asymmetric...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Palladium-Catalyzed Decarboxylative Asymmetric...