Binge alcohol use is not associated with alterations in striatal dopamine receptor binding or dopamine release.
Adolescent
Adult
Binge Drinking
/ metabolism
Central Nervous System Stimulants
/ pharmacology
Corpus Striatum
/ drug effects
Dopamine
/ metabolism
Ethanol
/ administration & dosage
Female
Humans
Male
Methylphenidate
/ pharmacology
Positron-Emission Tomography
Raclopride
/ pharmacology
Radioligand Assay
Receptors, Dopamine D2
/ metabolism
Receptors, Dopamine D3
/ metabolism
Young Adult
Alcohol
Binge drinking
Dopamine
Imaging
PET
Raclopride
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
04
06
2019
revised:
05
09
2019
accepted:
08
09
2019
pubmed:
2
11
2019
medline:
15
7
2020
entrez:
1
11
2019
Statut:
ppublish
Résumé
Previous imaging studies using Positron Emission Tomography (PET) have shown that alcohol use disorder (AUD) is associated with a decrease in dopamine type 2/3 receptor (D This study included 14 healthy controls (HC) and 14 young adult binge drinkers (BD), aged 18-25. The BD met National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria for binge drinking and the HC subjects were social drinkers. The subjects were scanned with [ There was no significant difference in the PET measures of D In this sample of 18-25-year-old binge drinkers without a diagnosis of a substance use disorder, there were no significant differences in D
Sections du résumé
BACKGROUND
Previous imaging studies using Positron Emission Tomography (PET) have shown that alcohol use disorder (AUD) is associated with a decrease in dopamine type 2/3 receptor (D
METHODS
This study included 14 healthy controls (HC) and 14 young adult binge drinkers (BD), aged 18-25. The BD met National Institute on Alcohol Abuse and Alcoholism (NIAAA) criteria for binge drinking and the HC subjects were social drinkers. The subjects were scanned with [
RESULTS
There was no significant difference in the PET measures of D
CONCLUSION
In this sample of 18-25-year-old binge drinkers without a diagnosis of a substance use disorder, there were no significant differences in D
Identifiants
pubmed: 31669800
pii: S0376-8716(19)30404-1
doi: 10.1016/j.drugalcdep.2019.107627
pmc: PMC6893096
mid: NIHMS1058148
pii:
doi:
Substances chimiques
Central Nervous System Stimulants
0
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
Methylphenidate
207ZZ9QZ49
Ethanol
3K9958V90M
Raclopride
430K3SOZ7G
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
107627Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA017648
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007294
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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