SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors.
Binding Sites
Butyrylcholinesterase
Carbamates
/ chemistry
Cell Survival
/ drug effects
Chloroplasts
Cholinesterase Inhibitors
/ chemistry
Electron Transport
/ drug effects
Humans
Inhibitory Concentration 50
Ligands
Molecular Docking Simulation
Photosystem II Protein Complex
Silicon
/ chemistry
Spinacia oleracea
Structure-Activity Relationship
THP-1 Cells
/ drug effects
CoMSA
IVE-PLS
in vitro cholinesterase inhibition
molecular docking
silicon-based carbamates
similarity-activity landscape index
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Oct 2019
29 Oct 2019
Historique:
received:
15
10
2019
revised:
25
10
2019
accepted:
27
10
2019
entrez:
2
11
2019
pubmed:
2
11
2019
medline:
28
3
2020
Statut:
epublish
Résumé
A set of 25 novel, silicon-based carbamate derivatives as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compounds were also tested for their inhibition potential on photosynthetic electron transport (PET) in spinach (
Identifiants
pubmed: 31671776
pii: ijms20215385
doi: 10.3390/ijms20215385
pmc: PMC6862691
pii:
doi:
Substances chimiques
Carbamates
0
Cholinesterase Inhibitors
0
Ligands
0
Photosystem II Protein Complex
0
Butyrylcholinesterase
EC 3.1.1.8
Silicon
Z4152N8IUI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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