Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets.
Adolescent
Adult
Autism Spectrum Disorder
/ diagnostic imaging
Brain
/ diagnostic imaging
Case-Control Studies
Cerebral Cortex
/ diagnostic imaging
Child
Female
Frontal Lobe
/ diagnostic imaging
Gyrus Cinguli
/ diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organ Size
Prefrontal Cortex
/ diagnostic imaging
Temporal Lobe
/ diagnostic imaging
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 10 2019
31 10 2019
Historique:
received:
22
03
2019
accepted:
01
10
2019
entrez:
2
11
2019
pubmed:
2
11
2019
medline:
4
3
2020
Statut:
epublish
Résumé
Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = -0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.
Identifiants
pubmed: 31673008
doi: 10.1038/s41467-019-13005-8
pii: 10.1038/s41467-019-13005-8
pmc: PMC6823355
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4958Subventions
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Commentaires et corrections
Type : ErratumIn
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