Pleiotropic Effects of Modified Citrus Pectin.
Adipose Tissue
/ drug effects
Aortic Valve Stenosis
/ drug therapy
Blood Proteins
Citrus
/ chemistry
Fibrosis
/ drug therapy
Galectin 3
/ antagonists & inhibitors
Galectins
Humans
Kidney Diseases
/ drug therapy
Liver Cirrhosis
/ drug therapy
Neoplasms
/ drug therapy
Pectins
/ pharmacology
Phytotherapy
cancer
cardiovascular
fibrosis
galectin
inflammation
pectasol
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
01 Nov 2019
01 Nov 2019
Historique:
received:
24
09
2019
revised:
24
10
2019
accepted:
28
10
2019
entrez:
6
11
2019
pubmed:
7
11
2019
medline:
3
4
2020
Statut:
epublish
Résumé
Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP.
Identifiants
pubmed: 31683865
pii: nu11112619
doi: 10.3390/nu11112619
pmc: PMC6893732
pii:
doi:
Substances chimiques
Blood Proteins
0
Galectin 3
0
Galectins
0
LGALS3 protein, human
0
citrus pectin
47EQO8LE7H
Pectins
89NA02M4RX
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Immunol. 1982 Mar;128(3):1221-8
pubmed: 6173426
Digestion. 2015;92(1):45-53
pubmed: 26202676
Hepatology. 2012 Jun;55(6):1954-64
pubmed: 22213244
Cell Biol Int. 2012 Jul;36(7):601-10
pubmed: 22214228
Cancer Res. 2010 Oct 1;70(19):7476-88
pubmed: 20719885
Aging (Albany NY). 2016 Jan;8(1):16-33
pubmed: 26752347
Front Physiol. 2019 Mar 22;10:267
pubmed: 30967790
Am J Transl Res. 2018 Aug 15;10(8):2402-2412
pubmed: 30210679
Can J Physiol Pharmacol. 2016 May;94(5):554-62
pubmed: 27010252
Blood. 2010 May 13;115(19):3939-48
pubmed: 20190189
Cancer Med. 2019 Aug;8(9):4315-4329
pubmed: 31197964
Cell Mol Biol (Noisy-le-grand). 1999 Dec;45(8):1191-202
pubmed: 10643968
Glycoconj J. 1994 Dec;11(6):527-32
pubmed: 7696855
Eur J Gastroenterol Hepatol. 2002 Feb;14(2):145-52
pubmed: 11981338
Asian Pac J Cancer Prev. 2013;14(12):7561-8
pubmed: 24460334
J Crohns Colitis. 2016 May;10(5):593-606
pubmed: 26786981
Cancer Biol Ther. 2013 Oct 1;14(10):897-906
pubmed: 23917726
Int J Mol Sci. 2017 Jul 31;18(8):null
pubmed: 28758988
Blood. 2012 Nov 29;120(23):4635-44
pubmed: 23065155
Biosci Rep. 2018 Dec 18;38(6):
pubmed: 30455396
J Bioenerg Biomembr. 2007 Feb;39(1):79-84
pubmed: 17318396
Glycobiology. 2013 Jun;23(6):654-63
pubmed: 23426722
Front Oncol. 2014 Jun 16;4:138
pubmed: 24982845
J Biol Chem. 2003 Feb 7;278(6):4127-34
pubmed: 12438311
PLoS One. 2015 Mar 20;10(3):e0115831
pubmed: 25794149
Forsch Komplementmed. 2007 Dec;14(6):358-64
pubmed: 18219211
Cancer Res. 2001 Jun 15;61(12):4851-7
pubmed: 11406562
Food Chem. 2017 Jul 15;227:245-254
pubmed: 28274429
J Mol Med (Berl). 2016 May;94(5):545-56
pubmed: 26631140
Biochim Biophys Acta. 2016 Apr;1863(4):562-71
pubmed: 26704388
Integr Cancer Ther. 2018 Dec;17(4):1225-1234
pubmed: 30043669
Glycoconj J. 2012 May;29(4):159-65
pubmed: 22562786
An Sist Sanit Navar. 2019 Aug 23;42(2):199-208
pubmed: 31317953
Integr Cancer Ther. 2010 Jun;9(2):197-203
pubmed: 20462856
Int J Mol Sci. 2018 Mar 25;19(4):null
pubmed: 29587379
Eur J Immunol. 2015 Feb;45(2):531-43
pubmed: 25359399
J Physiol. 2004 Jan 1;554(Pt 1):89-99
pubmed: 14678494
Cancer Res. 2003 Jul 1;63(13):3805-11
pubmed: 12839977
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4449-4458
pubmed: 31162551
Int J Biol Macromol. 2019 Jan;121:1-5
pubmed: 30292091
Circulation. 2004 Nov 9;110(19):3121-8
pubmed: 15520318
Evid Based Complement Alternat Med. 2017;2017:8379843
pubmed: 28900464
Cancer Metastasis Rev. 2014 Mar;33(1):285-94
pubmed: 24338002
Nat Med. 2000 Jan;6(1):100-2
pubmed: 10613833
Clin Sci (Lond). 2018 Jul 18;132(13):1471-1485
pubmed: 29674526
Int J Mol Sci. 2017 Nov 21;18(11):null
pubmed: 29160796
Altern Ther Health Med. 2019 Jul;25(4):20-24
pubmed: 31202207
Cancer Res. 2005 Sep 1;65(17):7546-53
pubmed: 16140916
Integr Cancer Ther. 2013 Mar;12(2):145-52
pubmed: 22532035
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):67-75
pubmed: 23117656
Apoptosis. 2005 Mar;10(2):267-75
pubmed: 15843888
Cancer Res. 1999 Aug 15;59(16):4148-54
pubmed: 10463621
Int J Gynecol Cancer. 2008 Jul-Aug;18(4):652-9
pubmed: 17892458
Dis Model Mech. 2018 Feb 5;11(2):
pubmed: 29361517
PLoS One. 2016 Nov 9;11(11):e0166272
pubmed: 27829066
J Am Heart Assoc. 2016 Nov 4;5(11):
pubmed: 27815266
Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46
pubmed: 22095546
Cell. 2016 Nov 3;167(4):973-984.e12
pubmed: 27814523
Cardiovasc Drugs Ther. 2014 Jun;28(3):237-46
pubmed: 24789662
Hypertension. 2016 Mar;67(3):606-12
pubmed: 26781273
Cell Death Discov. 2015 Nov 02;1:15047
pubmed: 27551476
FEBS Lett. 2000 May 19;473(3):311-5
pubmed: 10818231
Hypertension. 2015 Oct;66(4):767-75
pubmed: 26238446
Anticancer Res. 2015 Sep;35(9):4765-75
pubmed: 26254367
J Natl Cancer Inst. 1995 Mar 1;87(5):348-53
pubmed: 7853416
Inflamm Bowel Dis. 2011 Jan;17(1):260-7
pubmed: 20812334
Phytother Res. 2006 Oct;20(10):859-64
pubmed: 16835878
Am J Pathol. 2000 Mar;156(3):899-909
pubmed: 10702407
Cancer Res. 1997 Dec 1;57(23):5272-6
pubmed: 9393748
Carbohydr Polym. 2019 May 1;211:141-151
pubmed: 30824074
Neoplasia. 2007 Aug;9(8):662-70
pubmed: 17786185
Carbohydr Res. 2009 Sep 28;344(14):1788-91
pubmed: 19061992
JACC Heart Fail. 2015 Jan;3(1):59-67
pubmed: 25458174
J Cell Physiol. 2019 Dec;234(12):21817-21824
pubmed: 30471105
Cell Death Dis. 2010 Nov 18;1:e101
pubmed: 21368866
Med Chem. 2017;13(7):682-688
pubmed: 28266280
Sci Rep. 2019 Jul 3;9(1):9607
pubmed: 31270370
BMC Complement Altern Med. 2011 Aug 04;11:59
pubmed: 21816083
J Natl Cancer Inst. 1998 Jan 21;90(2):118-23
pubmed: 9450571
World J Gastroenterol. 2008 Dec 28;14(48):7386-91
pubmed: 19109874
Cancer Res. 2006 Mar 15;66(6):3114-9
pubmed: 16540661
Clin Sci (Lond). 2017 May 1;131(10):935-949
pubmed: 28360193
Prostate Cancer Prostatic Dis. 2003;6(4):301-4
pubmed: 14663471
Gut. 2007 Jan;56(1):43-51
pubmed: 16709662
Acta Pharmacol Sin. 2018 Dec;39(12):1885-1893
pubmed: 29769742
J Natl Cancer Inst. 1992 Mar 18;84(6):438-42
pubmed: 1538421
Endocrinology. 2015 Jan;156(1):147-56
pubmed: 25343273
PLoS One. 2013 Dec 18;8(12):e83481
pubmed: 24367597
Front Pharmacol. 2013 Oct 08;4:128
pubmed: 24115933
Int J Obes (Lond). 2016 Jun;40(6):1034-8
pubmed: 26853916
J Biol Chem. 2002 May 3;277(18):15819-27
pubmed: 11839755
Int J Biol Sci. 2016 Apr 28;12(6):746-56
pubmed: 27194951
Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):433-40
pubmed: 18096829
Asian Pac J Cancer Prev. ;18(8):2275-2285
pubmed: 28843267
Nat Rev Cancer. 2002 Aug;2(8):563-72
pubmed: 12154349
Int J Gynecol Cancer. 2007 Sep-Oct;17(5):1040-6
pubmed: 17433067
Circ Heart Fail. 2013 Jan;6(1):107-17
pubmed: 23230309
J Biol Chem. 2003 May 9;278(19):17360-7
pubmed: 12604608
Mol Med Rep. 2017 Jul;16(1):647-653
pubmed: 28560429
Altern Med Rev. 2000 Dec;5(6):546-52
pubmed: 11134977
J Hypertens. 2018 Feb;36(2):368-376
pubmed: 28858976
Stroke. 2018 Nov;49(11):2743-2751
pubmed: 30355205
Hypertension. 2015 Nov;66(5):961-9
pubmed: 26351031
J Bone Miner Res. 1994 Jun;9(6):873-81
pubmed: 8079662
Hypertension. 2019 Mar;73(3):602-611
pubmed: 30612490
Cell Mol Life Sci. 2003 Feb;60(2):267-76
pubmed: 12678492
PLoS One. 2013 Oct 09;8(10):e75361
pubmed: 24130706
Neoplasia. 2005 May;7(5):522-7
pubmed: 15967104
Int J Mol Med. 2018 Feb;41(2):599-614
pubmed: 29207027
Cancer Res. 2005 Sep 15;65(18):8350-8
pubmed: 16166312
Glycoconj J. 2007 Nov;24(8):497-507
pubmed: 17525829
J Natl Cancer Inst. 2002 Dec 18;94(24):1854-62
pubmed: 12488479
Biochem Mol Biol Int. 1995 Nov;37(5):833-41
pubmed: 8624488
Biochim Biophys Acta. 2006 Apr;1760(4):616-35
pubmed: 16478649
Altern Ther Health Med. 2008 Jul-Aug;14(4):34-8
pubmed: 18616067
J Biol Chem. 2011 Aug 26;286(34):29913-21
pubmed: 21715322
Clin Sci (Lond). 2017 Nov 6;131(22):2707-2719
pubmed: 28982723
PLoS One. 2011 Apr 08;6(4):e18683
pubmed: 21494626