A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.
Amino Acid Motifs
Antigen Presentation
Antigens, CD1d
/ chemistry
Binding Sites
Conserved Sequence
Epitopes, T-Lymphocyte
/ chemistry
Gene Rearrangement
High-Throughput Nucleotide Sequencing
Humans
Immunophenotyping
Lipids
/ chemistry
Models, Molecular
Mutation
Protein Binding
Protein Conformation
Protein Multimerization
Receptors, Antigen, T-Cell, alpha-beta
/ chemistry
Structure-Activity Relationship
T-Lymphocytes
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 12 2019
15 12 2019
Historique:
received:
29
07
2019
accepted:
09
10
2019
pubmed:
7
11
2019
medline:
27
5
2020
entrez:
8
11
2019
Statut:
ppublish
Résumé
High-throughput TCR sequencing allows interrogation of the human TCR repertoire, potentially connecting TCR sequences to antigenic targets. Unlike the highly polymorphic MHC proteins, monomorphic Ag-presenting molecules such as MR1, CD1d, and CD1b present Ags to T cells with species-wide TCR motifs. CD1b tetramer studies and a survey of the 27 published CD1b-restricted TCRs demonstrated a TCR motif in humans defined by the TCR β-chain variable gene 4-1 (TRBV4-1) region. Unexpectedly, TRBV4-1 was involved in recognition of CD1b regardless of the chemical class of the carried lipid. Crystal structures of two CD1b-specific TRBV4-1
Identifiants
pubmed: 31694911
pii: jimmunol.1900872
doi: 10.4049/jimmunol.1900872
pmc: PMC6904517
mid: NIHMS1541215
doi:
Substances chimiques
Antigens, CD1d
0
CD1D protein, human
0
Epitopes, T-Lymphocyte
0
Lipids
0
Receptors, Antigen, T-Cell, alpha-beta
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3395-3406Subventions
Organisme : NIAID NIH HHS
ID : R01 AI049313
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR048632
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111224
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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