ConSurf-DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins.
ConSurf
ConSurf-DB
binding site
evolutionary conservation
evolutionary rate
functional importance
Journal
Protein science : a publication of the Protein Society
ISSN: 1469-896X
Titre abrégé: Protein Sci
Pays: United States
ID NLM: 9211750
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
01
07
2019
revised:
05
11
2019
accepted:
06
11
2019
pubmed:
9
11
2019
medline:
22
9
2020
entrez:
9
11
2019
Statut:
ppublish
Résumé
Patterns observed by examining the evolutionary relationships among proteins of common origin can reveal the structural and functional importance of specific residue positions. In particular, amino acids that are highly conserved (i.e., their positions evolve at a slower rate than other positions) are particularly likely to be of biological importance, for example, for ligand binding. ConSurf is a bioinformatics tool for accurately estimating the evolutionary rate of each position in a protein family. Here we introduce a new release of ConSurf-DB, a database of precalculated ConSurf evolutionary conservation profiles for proteins of known structure. ConSurf-DB provides high-accuracy estimates of the evolutionary rates of the amino acids in each protein. A reliable estimate of a query protein's evolutionary rates depends on having a sufficiently large number of effective homologues (i.e., nonredundant yet sufficiently similar). With current sequence data, ConSurf-DB covers 82% of the PDB proteins. It will be updated on a regular basis to ensure that coverage remains high-and that it might even increase. Much effort was dedicated to improving the user experience. The repository is available at https://consurfdb.tau.ac.il/. BROADER AUDIENCE: By comparing a protein to other proteins of similar origin, it is possible to determine the extent to which each amino acid position in the protein evolved slowly or rapidly. A protein's evolutionary profile can provide valuable insights: For example, amino acid positions that are highly conserved (i.e., evolved slowly) are particularly likely to be of structural and/or functional importance, for example, for ligand binding and catalysis. We introduce here a new and improved version of ConSurf-DB, a continually updated database that provides precalculated evolutionary profiles of proteins with known structure.
Identifiants
pubmed: 31702846
doi: 10.1002/pro.3779
pmc: PMC6933843
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
258-267Informations de copyright
© 2019 The Authors. Protein Science published by Wiley Periodicals, Inc. on behalf of The Protein Society.
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